Title:
NITROGENOUS AROMATIC RING COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2002/032872
Kind Code:
A1
Abstract:
Compounds represented by the general formula (|) or salts thereof, or hydrates of both: (|) wherein A?g¿ is an optionally substituted 5- to 14-membered heterocyclic group, or the like; X?g¿ is O-, -S-, or the like; Y?g¿ is optionally substituted C¿6-14? aryl, a 5- to 14-membered heterocyclic group, or the like; and T?g1¿ is a group of the general formula (||) or the like: (||) [wherein E?g¿ is a single bond, -N(R?g2¿)-, or the like; R?g1¿ and R?g2¿ are each independently hydrogen, optionally substituted C¿1-6? alkyl, or the like; and Z?g¿ is C¿1-8? alkyl, C¿3-8? alicyclic hydrocarbyl, C¿6-14? aryl, or the like].
Inventors:
FUNAHASHI YASUHIRO (JP)
TSURUOKA AKIHIKO (JP)
MATSUKURA MASAYUKI (JP)
HANEDA TORU (JP)
FUKUDA YOSHIO (JP)
KAMATA JUNICHI (JP)
TAKAHASHI KEIKO (JP)
MATSUSHIMA TOMOHIRO (JP)
MIYAZAKI KAZUKI (JP)
NOMOTO KEN-ICHI (JP)
WATANABE TATSUO (JP)
OBAISHI HIROSHI (JP)
YAMAGUCHI ATSUMI (JP)
SUZUKI SACHI (JP)
NAKAMURA KATSUJI (JP)
MIMURA FUSAYO (JP)
YAMAMOTO YUJI (JP)
MATSUI JUNJI (JP)
MATSUI KENJI (JP)
YOSHIBA TAKAKO (JP)
SUZUKI YASUYUKI (JP)
ARIMOTO ITARU (JP)
TSURUOKA AKIHIKO (JP)
MATSUKURA MASAYUKI (JP)
HANEDA TORU (JP)
FUKUDA YOSHIO (JP)
KAMATA JUNICHI (JP)
TAKAHASHI KEIKO (JP)
MATSUSHIMA TOMOHIRO (JP)
MIYAZAKI KAZUKI (JP)
NOMOTO KEN-ICHI (JP)
WATANABE TATSUO (JP)
OBAISHI HIROSHI (JP)
YAMAGUCHI ATSUMI (JP)
SUZUKI SACHI (JP)
NAKAMURA KATSUJI (JP)
MIMURA FUSAYO (JP)
YAMAMOTO YUJI (JP)
MATSUI JUNJI (JP)
MATSUI KENJI (JP)
YOSHIBA TAKAKO (JP)
SUZUKI YASUYUKI (JP)
ARIMOTO ITARU (JP)
Application Number:
PCT/JP2001/009221
Publication Date:
April 25, 2002
Filing Date:
October 19, 2001
Export Citation:
Assignee:
EISAI CO LTD (JP)
FUNAHASHI YASUHIRO (JP)
TSURUOKA AKIHIKO (JP)
MATSUKURA MASAYUKI (JP)
HANEDA TORU (JP)
FUKUDA YOSHIO (JP)
KAMATA JUNICHI (JP)
TAKAHASHI KEIKO (JP)
MATSUSHIMA TOMOHIRO (JP)
MIYAZAKI KAZUKI (JP)
NOMOTO KEN ICHI (JP)
WATANABE TATSUO (JP)
OBAISHI HIROSHI (JP)
YAMAGUCHI ATSUMI (JP)
SUZUKI SACHI (JP)
NAKAMURA KATSUJI (JP)
MIMURA FUSAYO (JP)
YAMAMOTO YUJI (JP)
MATSUI JUNJI (JP)
MATSUI KENJI (JP)
YOSHIBA TAKAKO (JP)
SUZUKI YASUYUKI (JP)
ARIMOTO ITARU (JP)
FUNAHASHI YASUHIRO (JP)
TSURUOKA AKIHIKO (JP)
MATSUKURA MASAYUKI (JP)
HANEDA TORU (JP)
FUKUDA YOSHIO (JP)
KAMATA JUNICHI (JP)
TAKAHASHI KEIKO (JP)
MATSUSHIMA TOMOHIRO (JP)
MIYAZAKI KAZUKI (JP)
NOMOTO KEN ICHI (JP)
WATANABE TATSUO (JP)
OBAISHI HIROSHI (JP)
YAMAGUCHI ATSUMI (JP)
SUZUKI SACHI (JP)
NAKAMURA KATSUJI (JP)
MIMURA FUSAYO (JP)
YAMAMOTO YUJI (JP)
MATSUI JUNJI (JP)
MATSUI KENJI (JP)
YOSHIBA TAKAKO (JP)
SUZUKI YASUYUKI (JP)
ARIMOTO ITARU (JP)
International Classes:
C07D213/74; A61K31/4355; A61K31/437; A61K31/4375; A61K31/4409; A61K31/4418; A61K31/4439; A61K31/4545; A61K31/455; A61K31/47; A61K31/4709; A61K31/496; A61K31/505; A61K31/519; A61K31/5377; A61P3/10; A61P9/00; A61P9/10; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07D207/34; C07D213/26; C07D213/68; C07D213/73; C07D213/75; C07D213/81; C07D213/82; C07D215/18; C07D215/22; C07D215/233; C07D215/36; C07D215/38; C07D215/48; C07D239/34; C07D239/42; C07D239/46; C07D239/88; C07D249/04; C07D261/14; C07D277/48; C07D307/68; C07D319/06; C07D401/04; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D491/04; C07D491/048; C07D495/04; A61K; A61P; C07D; (IPC1-7): C07D213/74; C07D213/75; C07D215/48; C07D239/47; C07D401/12; C07D401/14; C07D413/12; C07D405/12; C07D409/12; C07D417/12; C07D417/14; C07D471/14; C07D491/048; C07D495/04; A61K31/4709; A61K31/47; A61K31/5377; A61K31/496; A61K31/4545; A61K31/519; A61K31/44; A61K31/437; A61K31/4439; A61K31/505; A61P9/00; A61P9/10; A61P35/00; A61P27/02; A61P29/00; A61P19/02
Domestic Patent References:
| WO2000043366A1 | 2000-07-27 | |||
| WO1997017329A1 | 1997-05-15 | |||
| WO2001047931A1 | 2001-07-05 | |||
| WO2001047890A1 | 2001-07-05 | |||
| WO1998037079A1 | 1998-08-27 |
Foreign References:
| JPH11158149A | 1999-06-15 | |||
| US4764454A | 1988-08-16 |
Other References:
SPACEY G.D. ET AL.: "Indolocarbazoles: potent and selective inhibitors of platelet-derived growth factor receptor autophosphorylation", BIOCHEMICAL PHARMACOLOGY, vol. 55, no. 3, 1998, pages 261 - 271, XP002907870
FOLKMAN A.J.: "New perspectives in clinical oncology from angiogenesis research", EUROPEAN JOURNAL OF CANCER, vol. 32, no. 14, 1996, pages 2534 - 2539, XP002907871
DEPLANQUE G. AND HARRIS A.L.: "Anti-angiogenic agents: clinical trial design and therapies in development", EUROPEAN JOURNAL OF CANCER, vol. 36, no. 13, August 2000 (2000-08-01), pages 1713 - 1724, XP002907872
KOTVA R. AND CERNY A. AND SEMONSKY M.: "Substances with antineoplastic activity. LIII. N. (delta-(4-pyrrolo(2,3-d)pyrimidinylthio)valeryl) amino acids and analogous derivatives of di- and triglycine", CZECH. CHEM. COMMUN., vol. 38, no. 5, 1973, pages 1438 - 1444, XP002907873
BUSSOLINO F. ET AL.: "Role of soluble mediators in angiogenesis", EUROPEAN JOURNAL OF CANCER, vol. 32, no. 14, 1996, pages 2401 - 2412, XP002907874
WANG F. AND SCHWABACHER A.W.: "A convenient set of bidentate pyridine ligands for combinatorial synthesis", TETRAHEDRON LETT., vol. 40, no. 26, 1999, pages 4779 - 4782, XP004168642
See also references of EP 1415987A4
FOLKMAN A.J.: "New perspectives in clinical oncology from angiogenesis research", EUROPEAN JOURNAL OF CANCER, vol. 32, no. 14, 1996, pages 2534 - 2539, XP002907871
DEPLANQUE G. AND HARRIS A.L.: "Anti-angiogenic agents: clinical trial design and therapies in development", EUROPEAN JOURNAL OF CANCER, vol. 36, no. 13, August 2000 (2000-08-01), pages 1713 - 1724, XP002907872
KOTVA R. AND CERNY A. AND SEMONSKY M.: "Substances with antineoplastic activity. LIII. N. (delta-(4-pyrrolo(2,3-d)pyrimidinylthio)valeryl) amino acids and analogous derivatives of di- and triglycine", CZECH. CHEM. COMMUN., vol. 38, no. 5, 1973, pages 1438 - 1444, XP002907873
BUSSOLINO F. ET AL.: "Role of soluble mediators in angiogenesis", EUROPEAN JOURNAL OF CANCER, vol. 32, no. 14, 1996, pages 2401 - 2412, XP002907874
WANG F. AND SCHWABACHER A.W.: "A convenient set of bidentate pyridine ligands for combinatorial synthesis", TETRAHEDRON LETT., vol. 40, no. 26, 1999, pages 4779 - 4782, XP004168642
See also references of EP 1415987A4
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Okura-honkan 6-12 Ginza 2-chome Chuo-ku, Tokyo, JP)
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