Title:
NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/019106
Kind Code:
A1
Abstract:
Provided are a nitrogenous heterocyclic aromatic compound, a preparation method therefor, a pharmaceutical composition thereof, and an application thereof. The nitrogenous heterocyclic aromatic compound can be used for treating and/or preventing various diseases mediated by ALK5.
Inventors:
XU ZUSHENG (CN)
LOU YANGTONG (CN)
CHEN LI (CN)
LOU YANGTONG (CN)
CHEN LI (CN)
Application Number:
PCT/CN2017/091940
Publication Date:
February 01, 2018
Filing Date:
July 06, 2017
Export Citation:
Assignee:
SHANGHAI YINGLI PHARM CO LTD (CN)
International Classes:
A61K31/437; C07D401/10; A61K31/444; A61P3/10; A61P13/12; A61P17/02; A61P19/02; A61P19/10; A61P27/02; A61P31/12; A61P35/00; C07D405/10
Domestic Patent References:
| WO2004111036A1 | 2004-12-23 | |||
| WO2012002680A2 | 2012-01-05 | |||
| WO2009022171A1 | 2009-02-19 | |||
| WO2009133070A1 | 2009-11-05 | |||
| WO2004048383A1 | 2004-06-10 | |||
| WO2004013135A1 | 2004-02-12 | |||
| WO2002094833A1 | 2002-11-28 |
Foreign References:
| JP2012193123A | 2012-10-11 | |||
| CN102695511A | 2012-09-26 | |||
| CN103025731A | 2013-04-03 | |||
| CN201610613592A | 2016-07-29 |
Other References:
LI YOU-GUI. ET AL.: "Bulky Phosphane Ligand for Monoselective Ruthenium-Cata-lyzed, Directed o-C-H Arylation with Challenging Aryl Chlorides", SYNLETT, vol. 28, 9 November 2016 (2016-11-09), pages 499 - 503, XP055582242, ISSN: 0936-5214, DOI: 10.1055/s-0036-1588635
NATURE, vol. 425, 2003, pages 577
NAT REV DRUG DISCOV., vol. 11, no. 10, October 2012 (2012-10-01), pages 790 - 811
PHARMACOLOGY & THERAPEUTICS, vol. 147, 2015, pages 22 - 31
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
T. W. GREENE; P. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
L. FIESER; M. FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
NATURE, vol. 425, 2003, pages 577
NAT REV DRUG DISCOV., vol. 11, no. 10, October 2012 (2012-10-01), pages 790 - 811
PHARMACOLOGY & THERAPEUTICS, vol. 147, 2015, pages 22 - 31
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
T. W. GREENE; P. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
L. FIESER; M. FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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