Title:
NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE
Document Type and Number:
WIPO Patent Application WO/2017/148391
Kind Code:
A1
Abstract:
Disclosed are a nitrogenous heterocyclic compound, intermediates, a preparation method, a composition and use thereof. The nitrogenous heterocyclic compound in the present invention is as shown in formula I. The compound has a high inhibitory activity towards ErbB2 tyrosine kinase and a relatively good inhibitory activity towards human breast cancer BT-474 and human gastric cancer cell NCI-N87 which express ErbB2 at a high level, and at the same time has a relatively weak inhibitory activity towards EGFR kinase. Namely, the compound is a highly selective small-molecule inhibitor targeted at ErbB2, and hence it has a high degree of safety, and can effectively enlarge the safety window in the process of taking the drug.
Inventors:
XIA GUANGXIN (CN)
LI DI (CN)
ZUO HONGJIAN (CN)
WU GUANGSHENG (CN)
DUAN LINGJUN (CN)
ZHANG JING (CN)
MAO YU (CN)
LIU YANJUN (CN)
LI DI (CN)
ZUO HONGJIAN (CN)
WU GUANGSHENG (CN)
DUAN LINGJUN (CN)
ZHANG JING (CN)
MAO YU (CN)
LIU YANJUN (CN)
Application Number:
PCT/CN2017/075332
Publication Date:
September 08, 2017
Filing Date:
March 01, 2017
Export Citation:
Assignee:
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61P35/00
Domestic Patent References:
| WO2005028443A2 | 2005-03-31 |
Foreign References:
| CN1659145A | 2005-08-24 | |||
| CN101348467A | 2009-01-21 |
Other References:
See also references of EP 3424928A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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