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Title:
NITROGENOUS HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/1993/007124
Kind Code:
A1
Abstract:
A nitrogenous heterocyclic compound represented by general formula (I) or a pharmacologically acceptable salt thereof, efficacious in treating various ischemic cardiac diseases, wherein ring A represents a benzene, pyridine or cyclohexane ring; ring B represents a pyridine, pyrimidine or imidazole ring; R1, R2, R3 and R4 represent each hydrogen, halogen, lower alkoxy, etc.; R5 represents -NR11R12 (wherein R11 and R12 represent each hydrogen, lower alkyl, etc.), etc.; and R6 represents (a) (wherein R19 represents hydrogen, lower alkyl, etc.; R20, R21 and R22 represent each hydrogen, halogen, hydroxy, etc.; and r represents an integer of 0.1 to 8), etc.

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Inventors:
TAKASE YASUTAKA (JP)
WATANABE NOBUHISA (JP)
MATSUI MAKOTO (JP)
IKUTA HIRONORI (JP)
KIMURA TEIJI (JP)
SAEKI TAKAO (JP)
ADACHI HIDEYUKI (JP)
TOKUMURA TADAKAZU (JP)
Application Number:
PCT/JP1992/001258
Publication Date:
April 15, 1993
Filing Date:
September 30, 1992
Export Citation:
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Assignee:
EISAI CO LTD (JP)
International Classes:
A61K31/415; A61K31/4184; A61K31/4427; A61K31/443; A61K31/445; A61K31/454; A61K31/4706; A61K31/4709; C07D215/42; A61K31/496; A61K31/505; A61K31/517; A61K31/519; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P37/00; A61P43/00; B60S1/16; B60S1/24; C07D215/48; C07D235/06; C07D235/08; C07D239/78; C07D239/84; C07D239/86; C07D239/88; C07D239/90; C07D239/94; C07D239/95; C07D239/96; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/06; C07D405/12; C07D405/14; C07D413/12; C07D471/04; C07D491/04; C07D491/056; C07D521/00; F16C7/02; F16C11/04; (IPC1-7): A61K31/47; A61K31/505; C07D215/00; C07D235/00; C07D239/72; C07D239/84; C07D239/94; C07D239/95
Foreign References:
JPS57171973A1982-10-22
JPS5933264A1984-02-23
JPS5371088A1978-06-24
JPS5879983A1983-05-13
JPS6396174A1988-04-27
JPS6474A1989-01-05
JPS55160776A1980-12-13
JPS61167688A1986-07-29
JPS63216884A1988-09-09
JPS6133185A1986-02-17
JPS61140568A1986-06-27
JPH0317068A1991-01-25
Other References:
J. Med. Chem., 28(1), 12-17 (1985).
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