Title:
NITROSATED AD NITROSYLATED DIURETIC COMPOUDS, COMPOSITIONS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2005023183
Kind Code:
A3
Abstract:
The invention describes novel nitrosated and/or nitrosylated diuretic compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated diuretic compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one diuretic compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; and (1) treating nephropathy.
Inventors:
GARVEY DAVID S (US)
LETTS L GORDON (US)
WORCEL MANUEL (US)
EARL RICHARD A (US)
EZAWA MAIKO (US)
FANG XINQIN (US)
KHANAPURE SUBHASH P (US)
LIN CHIA-EN (US)
RANATUNGE RAMANI R (US)
STEVENSON CHERI A (US)
LETTS L GORDON (US)
WORCEL MANUEL (US)
EARL RICHARD A (US)
EZAWA MAIKO (US)
FANG XINQIN (US)
KHANAPURE SUBHASH P (US)
LIN CHIA-EN (US)
RANATUNGE RAMANI R (US)
STEVENSON CHERI A (US)
Application Number:
PCT/US2004/026911
Publication Date:
October 13, 2005
Filing Date:
August 20, 2004
Export Citation:
Assignee:
NITROMED INC (US)
GARVEY DAVID S (US)
LETTS L GORDON (US)
WORCEL MANUEL (US)
EARL RICHARD A (US)
EZAWA MAIKO (US)
FANG XINQIN (US)
KHANAPURE SUBHASH P (US)
LIN CHIA-EN (US)
RANATUNGE RAMANI R (US)
STEVENSON CHERI A (US)
GARVEY DAVID S (US)
LETTS L GORDON (US)
WORCEL MANUEL (US)
EARL RICHARD A (US)
EZAWA MAIKO (US)
FANG XINQIN (US)
KHANAPURE SUBHASH P (US)
LIN CHIA-EN (US)
RANATUNGE RAMANI R (US)
STEVENSON CHERI A (US)
International Classes:
A61K31/4523; A61K31/517; A61K31/5415; A61K31/549; C07D211/00; C07D285/22; C07D295/00; C07D307/00; C07D417/12; C07D417/14; A61K; (IPC1-7): C07D417/12; A61K31/4523; A61K31/5415; C07D211/00; C07D295/00; C07D307/00; C07D417/14
Foreign References:
| US4992451A | 1991-02-12 |
Other References:
See also references of EP 1668008A4
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