Title:
NK1 RECEPTOR ANTAGONIST COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2008/047709
Kind Code:
A1
Abstract:
Disclosed is an NK1 receptor antagonist composition comprising a maltooligosaccharide having an antagonistic activity on an NK1 receptor as an active ingredient. Preferably, the maltooligosaccharide is contained in the NK1 receptor antagonist composition in an amount of 0.000001 to 70 wt%. The NK1 receptor antagonist composition may contain various materials in addition to the active ingredient and can be prepared into various forms such as an external preparation, an internal preparation, a food and a beverage. The NK1 receptor antagonist composition has enough high safety to be used as a pharmaceutical preparation and has a satisfactorylevel of therapeutic effect.
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Inventors:
UOZUMI TAKUYA (JP)
MORISHITA SATORU (JP)
TANAKA YOSHIMASA (JP)
YUMOTO MAYUMI (JP)
MORISHITA SATORU (JP)
TANAKA YOSHIMASA (JP)
YUMOTO MAYUMI (JP)
Application Number:
PCT/JP2007/069959
Publication Date:
April 24, 2008
Filing Date:
October 12, 2007
Export Citation:
Assignee:
LION CORP (JP)
UOZUMI TAKUYA (JP)
MORISHITA SATORU (JP)
TANAKA YOSHIMASA (JP)
YUMOTO MAYUMI (JP)
UOZUMI TAKUYA (JP)
MORISHITA SATORU (JP)
TANAKA YOSHIMASA (JP)
YUMOTO MAYUMI (JP)
International Classes:
C07H3/04; A23L1/30; A23L2/52; A61K8/60; A61K8/73; A61K31/702; A61P1/04; A61P1/08; A61P3/04; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/32; A61P27/02; A61P29/00; A61P43/00; A61Q7/00; A61Q19/00; C07H3/06
Domestic Patent References:
| WO1997000075A1 | 1997-01-03 |
Foreign References:
| JP2002308783A | 2002-10-23 | |||
| JPH05294837A | 1993-11-09 | |||
| JPH01117831A | 1989-05-10 | |||
| JP2005527498A | 2005-09-15 | |||
| JPH07304649A | 1995-11-21 | |||
| JP2783520B2 | 1998-08-06 | |||
| JP2006089499A | 2006-04-06 |
Other References:
YOSHINO K.: "Oligosaccharide no Ko-mouse Sesshoku Kabin-sho Sayo ni Kansuru Kenkyu", J. TECHNOLOGY AND EDUCATION, vol. 11, no. 1, 2004, pages 37 - 41, XP003022306
TAKAYANAGI, K.: "Receptors on Cell Membrane", 1998, NANZANDO
KRAMER MS ET AL., SCIENCE, vol. 281, no. 5383, 1998, pages 1640 - 1645
GESZTESI Z ET AL., ANESTHESIOLOGY, vol. 93, no. 4, 2000, pages 931 - 937
ZUBRZYCKA M ET AL., ENDOCRINE REGULATIONS, vol. 34, no. 1, 2000, pages 13 - 18
ROST K ET AL., MED MONATSSCHR PHARM, vol. 29, no. 6, 2006, pages 200 - 205
R. M. SNIDER ET AL., SCIENCE, vol. 251, 1991, pages 435 - 437
M. CAESER ET AL., BR. J.: PHARMACOL., vol. 109, 1993, pages 918 - 24
RENGANATHAN M ET AL., J NEUROPHYSIOL., vol. 84, no. 2, 2000, pages 710 - 82
See also references of EP 2075252A4
TAKAYANAGI, K.: "Receptors on Cell Membrane", 1998, NANZANDO
KRAMER MS ET AL., SCIENCE, vol. 281, no. 5383, 1998, pages 1640 - 1645
GESZTESI Z ET AL., ANESTHESIOLOGY, vol. 93, no. 4, 2000, pages 931 - 937
ZUBRZYCKA M ET AL., ENDOCRINE REGULATIONS, vol. 34, no. 1, 2000, pages 13 - 18
ROST K ET AL., MED MONATSSCHR PHARM, vol. 29, no. 6, 2006, pages 200 - 205
R. M. SNIDER ET AL., SCIENCE, vol. 251, 1991, pages 435 - 437
M. CAESER ET AL., BR. J.: PHARMACOL., vol. 109, 1993, pages 918 - 24
RENGANATHAN M ET AL., J NEUROPHYSIOL., vol. 84, no. 2, 2000, pages 710 - 82
See also references of EP 2075252A4
Attorney, Agent or Firm:
SAKAI, Hiroaki (Kasumigaseki Building2-5, Kasumigaseki 3-chom, Chiyoda-ku Tokyo 20, JP)
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