Title:
NLRP3 PROTEIN DEGRADATION INDUCING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/098108
Kind Code:
A1
Abstract:
The present invention relates to an NLRP3 protein degradation inducing compound. Specifically, the present invention relates to a bifunctional compound in which an NLRP3 protein-binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker, a method for preparing same, a method for degrading an NLRP3 protein using same, and a use for preventing or treating NLRP3 inflammasome-related diseases.
Inventors:
RYU SOO HEE (KR)
RYU JI HOON (KR)
LEE HWA JIN (KR)
MIN IM SUK (KR)
LEE HAN KYU (KR)
LEE JUN KYU (KR)
LEE JI SU (KR)
KOH SU YOUN (KR)
KIM SEONG HOON (KR)
CHAE HYANG JI (KR)
RYU JI HOON (KR)
LEE HWA JIN (KR)
MIN IM SUK (KR)
LEE HAN KYU (KR)
LEE JUN KYU (KR)
LEE JI SU (KR)
KOH SU YOUN (KR)
KIM SEONG HOON (KR)
CHAE HYANG JI (KR)
Application Number:
PCT/KR2021/015860
Publication Date:
May 12, 2022
Filing Date:
November 04, 2021
Export Citation:
Assignee:
UPPTHERA (KR)
International Classes:
C07D401/14; A61K31/427; A61K31/454; C07D401/04; C07D417/14
Domestic Patent References:
| WO2019140380A1 | 2019-07-18 | |||
| WO2019109415A1 | 2019-06-13 |
Foreign References:
| KR20170109678A | 2017-09-29 | |||
| KR20180097530A | 2018-08-31 |
Other References:
HILL JAMES R.; COLL REBECCA C.; SCHRODER KATE; ROBERTSON AVRIL A.B.: "Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 61, no. 19, 16 March 2020 (2020-03-16), Amsterdam , NL , XP086137104, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2020.151849
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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