Title:
NON-CELLULAR ROOT CANAL FILLER AND NON-CELLULAR DENTAL TISSUE REGENERATION PROMOTING KIT
Document Type and Number:
WIPO Patent Application WO/2019/065478
Kind Code:
A1
Abstract:
The present invention provides a non-cellular dental tissue regeneration promoting kit capable of effectively regenerating dental tissue even when autologous or allogeneic stem cells or a stem cell-derived component is not transplanted. The present invention has a non-cellular root canal filler having: a pretreatment agent including serine protease; a regeneration promoting compound including at least one among a CCR3 antagonist, a CCL11 neutralizing antibody, and an ALK5 inhibitor; and an extracellular matrix. Preferably, the present invention is used for a middle and aged individual.
Inventors:
NAKASHIMA MISAKO (JP)
IOHARA KOICHIRO (JP)
IOHARA KOICHIRO (JP)
Application Number:
PCT/JP2018/034948
Publication Date:
April 04, 2019
Filing Date:
September 21, 2018
Export Citation:
Assignee:
NAT CT GERIATRICS & GERONTOLOGY (JP)
International Classes:
A61L27/22; A61K35/35; A61K38/19; A61K38/48; A61K39/395; A61K45/00; A61L27/26; A61L27/40; A61L27/54; A61P1/02
Domestic Patent References:
| WO2017170996A1 | 2017-10-05 |
Foreign References:
| JPS5621105B2 | 1981-05-18 | |||
| JPS6031658B2 | 1985-07-23 | |||
| JPS5748194B2 | 1982-10-14 | |||
| JPS5939559B2 | 1984-09-25 | |||
| JP2016072306A | 2016-05-09 | |||
| JP2017013572W | 2017-03-31 |
Other References:
GOLDBERG, MICHEL ET AL.: "Inflammatory and immunological aspects of dental pulp repair", PHARMACOLOGICAL RESEARCH, vol. 58, 2008, pages 137 - 147, XP025506780, DOI: 10.1016/j.phrs.2008.05.013
LIN, PO SHUEN ET AL.: "Transforming growth factor beta1 down-regulates Runx-2 and alkaline phosphatase activity of human dental pulp cells via ALK5/Smad2/3 signaling", ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL ENDOD, vol. 111, 2011, pages 394 - 400, XP028357915, DOI: 10.1016/j.tripleo.2010.09.079
CHANG, HSIAO HUA ET AL.: "Role of ALK5/Smad2/3 and MEK1/ERK Signaling in Transforming Growth Factor Beta 1-modulated Growth, Collagen Turnover, and Differentiation of Stem Cells from Apical Papilla of Human Tooth", JOURNAL OF ENDODONTICS, vol. 41, no. 8, 2015, pages 1272 - 1280, XP009519677, DOI: 10.1016/j.joen.2015.03.022
HAYASHI, YUKI ET AL.: "Review of mechanism for recovering amount of dental pulp regeneration by means of continuous administration of anti-CCLll antibody in elderly mouse", REGENERATIVE MEDICINE, vol. 16, no. Suppl., 1 February 2017 (2017-02-01), pages 419, XP009519637, ISSN: 1347-7919
NAKASHIMA M.IOHARA K.MURAKAMI M.NAKAMURA H.SATO Y.ARIJI Y.MATSUSHITA K.: "Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: A pilot clinical study", STEM CELL RES THERAPY, vol. 8, no. 1, 2017, pages 61
GALLER KM.: "Clinical procedures for revitalization: current knowledge and considerations", INT ENDOD J., vol. 49, no. 10, October 2016 (2016-10-01), pages 926 - 36
KONTAKIOTIS EGFILIPPATOS CGTZANETAKIS GNAGRAFIOTI A.: "Regenerative endodontic therapy: a data analysis of clinical protocols", J ENDOD., vol. 41, no. 2, 2015, pages 146 - 54
DEL FABBRO MLOLATO ABUCCHI CTASCHIERI SWEINSTEIN RL: "Autologous platelet concentrates for pulp and dentin regeneration: a literature review of animal studies", J ENDOD., vol. 42, no. 2, 2016, pages 250 - 7, XP029394758, DOI: 10.1016/j.joen.2015.10.012
YANG J.YUAN G.CHEN Z.: "Pulp Regeneration: Current Approaches and Future Challenges", FRONT PHYSIOL., vol. 7, 2016, pages 58
HE LKIM SGGONG QZHONG JWANG SZHOU XYE LLING JMAO JJ.: "Regenerative endodontics for adult patients", J ENDOD., vol. 43, no. 9S, 2017, pages S57 - S64
IOHARA KMURAKAMI MTAKEUCHI NOSAKO YITO MISHIZAKA RUTUNOMIYA SNAKAMURA HMATSUSHITA KNAKASHIMA M: "A novel combinatorial therapy with pulp stem cells and granulocyte colony-stimulating factor for total pulp regeneration", STEM CELLS TRANSL. MED., vol. 2, no. 7, 2013, pages 521 - 533
CAO YSONG MKIM ESHON WCHUGAL NBOGEN GLIN LKIM RHPARK NHKANG MK: "Pulp-dentin Regeneration: Current State and Future Prospects", J DENT RES., vol. 94, no. 11, 2015, pages 1544 - 51
YANG JYUAN GCHEN Z.: "Pulp Regeneration: Current Approaches and Future Challenges", FRONT PHYSIOL, vol. 7, 2016, pages 58
KAWAMURA RHAYASHI YMURAKAMI HNAKASHIMA M: "EDTA soluble chemical components and the conditioned medium from mobilized dental pulp stem cells contain an inductive microenvironment, promoting cell proliferation, migration and odontoblastic differentiation", STEM CELL RES. THER., vol. 7, no. 1, 2016, pages 77
NOGUCHI YOSHIKUNI ET AL., JAPANESE JOURNAL OF DERMATOLOGY AND VENEREOLOGY, vol. 64, 1954, pages 497 - 506
IOHARA ET AL., TISSUE ENGINEERING PART A, 2011
WANG H ET AL., INVEST OPHTHALMOL VIS SCI., 2011
LIN, PO SHUEN ET AL.: "Transforming growth factor beta1 down-regulates Runx-2 and alkaline phosphatase activity of human dental pulp cells via ALK5/Smad2/3 signaling", ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL ENDOD, vol. 111, 2011, pages 394 - 400, XP028357915, DOI: 10.1016/j.tripleo.2010.09.079
CHANG, HSIAO HUA ET AL.: "Role of ALK5/Smad2/3 and MEK1/ERK Signaling in Transforming Growth Factor Beta 1-modulated Growth, Collagen Turnover, and Differentiation of Stem Cells from Apical Papilla of Human Tooth", JOURNAL OF ENDODONTICS, vol. 41, no. 8, 2015, pages 1272 - 1280, XP009519677, DOI: 10.1016/j.joen.2015.03.022
HAYASHI, YUKI ET AL.: "Review of mechanism for recovering amount of dental pulp regeneration by means of continuous administration of anti-CCLll antibody in elderly mouse", REGENERATIVE MEDICINE, vol. 16, no. Suppl., 1 February 2017 (2017-02-01), pages 419, XP009519637, ISSN: 1347-7919
NAKASHIMA M.IOHARA K.MURAKAMI M.NAKAMURA H.SATO Y.ARIJI Y.MATSUSHITA K.: "Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: A pilot clinical study", STEM CELL RES THERAPY, vol. 8, no. 1, 2017, pages 61
GALLER KM.: "Clinical procedures for revitalization: current knowledge and considerations", INT ENDOD J., vol. 49, no. 10, October 2016 (2016-10-01), pages 926 - 36
KONTAKIOTIS EGFILIPPATOS CGTZANETAKIS GNAGRAFIOTI A.: "Regenerative endodontic therapy: a data analysis of clinical protocols", J ENDOD., vol. 41, no. 2, 2015, pages 146 - 54
DEL FABBRO MLOLATO ABUCCHI CTASCHIERI SWEINSTEIN RL: "Autologous platelet concentrates for pulp and dentin regeneration: a literature review of animal studies", J ENDOD., vol. 42, no. 2, 2016, pages 250 - 7, XP029394758, DOI: 10.1016/j.joen.2015.10.012
YANG J.YUAN G.CHEN Z.: "Pulp Regeneration: Current Approaches and Future Challenges", FRONT PHYSIOL., vol. 7, 2016, pages 58
HE LKIM SGGONG QZHONG JWANG SZHOU XYE LLING JMAO JJ.: "Regenerative endodontics for adult patients", J ENDOD., vol. 43, no. 9S, 2017, pages S57 - S64
IOHARA KMURAKAMI MTAKEUCHI NOSAKO YITO MISHIZAKA RUTUNOMIYA SNAKAMURA HMATSUSHITA KNAKASHIMA M: "A novel combinatorial therapy with pulp stem cells and granulocyte colony-stimulating factor for total pulp regeneration", STEM CELLS TRANSL. MED., vol. 2, no. 7, 2013, pages 521 - 533
CAO YSONG MKIM ESHON WCHUGAL NBOGEN GLIN LKIM RHPARK NHKANG MK: "Pulp-dentin Regeneration: Current State and Future Prospects", J DENT RES., vol. 94, no. 11, 2015, pages 1544 - 51
YANG JYUAN GCHEN Z.: "Pulp Regeneration: Current Approaches and Future Challenges", FRONT PHYSIOL, vol. 7, 2016, pages 58
KAWAMURA RHAYASHI YMURAKAMI HNAKASHIMA M: "EDTA soluble chemical components and the conditioned medium from mobilized dental pulp stem cells contain an inductive microenvironment, promoting cell proliferation, migration and odontoblastic differentiation", STEM CELL RES. THER., vol. 7, no. 1, 2016, pages 77
NOGUCHI YOSHIKUNI ET AL., JAPANESE JOURNAL OF DERMATOLOGY AND VENEREOLOGY, vol. 64, 1954, pages 497 - 506
IOHARA ET AL., TISSUE ENGINEERING PART A, 2011
WANG H ET AL., INVEST OPHTHALMOL VIS SCI., 2011
Attorney, Agent or Firm:
MAEDA & PARTNERS (JP)
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