Title:
NON-CODING RNA-MEDIATED NEUROLOGICAL DISEASE TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/104028
Kind Code:
A1
Abstract:
A method for producing neurons from non-neuronal cells is provided, and comprises: by means of enhancing or reducing the expression or activity of certain miRNAs and/or lncRNAs in non-neuronal cells, transdifferentiating or reprogramming the non-neuronal cells into neurons. Also provided is the use of reagents that enhance or reduce the expression or activity of certain miRNAs and/or IncRNAs in the prevention and/or treatment of diseases related to neuronal dysfunction or death.
Inventors:
ZHOU HAIBO (CN)
HU XINDE (CN)
SU JINLIN (CN)
HU XINDE (CN)
SU JINLIN (CN)
Application Number:
PCT/CN2022/136909
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
SHANGHAI GENEMAGIC BIOSCIENCES CO LTD (CN)
International Classes:
A61K35/30; C12N5/10; A61P25/00; C12N5/0793; C12Q1/68
Foreign References:
| US20150037299A1 | 2015-02-05 | |||
| US20150037298A1 | 2015-02-05 | |||
| CN109674809A | 2019-04-26 | |||
| US20190015453A1 | 2019-01-17 |
Other References:
YANG HUI, WAN GUANG, GAO XUAN-ZHAO, LIU YI, WANG SHOU-CHUN: "let-7a inhibits MAP4K3/MKK4/JNK signaling pathway to decrease neuronal apoptosis in rats with intracerebral hemorrhage", CHINESE JOURNAL OF PATHOPHYSIOLOGY, vol. 36, no. 6, 25 June 2022 (2022-06-25), pages 1055 - 1062, XP093068818, DOI: 1000-4718(2020)06-1055-08
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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