Title:
NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED VERSIONS OF PLANT G PROTEIN-COUPLED RECEPTOR: GCR1
Document Type and Number:
WIPO Patent Application WO2002100882
Kind Code:
A3
Abstract:
The invention relates to transmembrane receptors for which the endogenous ligand has not been identified, and specifically to a plant GPCR ("GCR1") that has been altered to establish constitutive activity of the receptor. In some embodiments, the altered versions of GCR1 are used for the direct identification of candidate compounds as receptor agonists, inverse agonists or partial agonists for use in, for example and not limitation, herbicidal relevance; germination; growth elongation; seed dormancy; and fruit and vegetable ripening and development. In some embodiments, altered versions of GCR1 are used to modulate physiological processes in a plant. The invention further relates to plants comprising constitutively activated non-endogenous GPCRs.
Inventors:
COLUCCI GABRIELLA (US)
Application Number:
PCT/US2002/017809
Publication Date:
April 10, 2003
Filing Date:
June 05, 2002
Export Citation:
Assignee:
ARENA PHARM INC (US)
COLUCCI GABRIELLA (US)
COLUCCI GABRIELLA (US)
International Classes:
C07K14/705; C12N15/29; C12N15/82; (IPC1-7): C07K14/415; C12N15/29; C12N15/82; G01N33/53; A01H3/00; A01H5/00
Domestic Patent References:
| WO1998000545A2 | 1998-01-08 |
Other References:
JOSEFSSON ET AL.: "Cloning of a putative G-protein-coupled receptor from arabidopsis thaliana", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 249, 1997, pages 415 - 420, XP002050578
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