Title:
NON-HUMAN ANIMALS EXPRESSING ANTIBODIES HAVING A COMMON LIGHT CHAIN
Document Type and Number:
WIPO Patent Application WO/2012/148873
Kind Code:
A4
Abstract:
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided.
Inventors:
MCWHIRTER JOHN (US)
MACDONALD LYNN (US)
STEVENS SEAN (US)
DAVIS SAMUEL (US)
BUCKLER DAVID R (US)
HOSIAWA KAROLINA A (US)
MURPHY ANDREW J (US)
MACDONALD LYNN (US)
STEVENS SEAN (US)
DAVIS SAMUEL (US)
BUCKLER DAVID R (US)
HOSIAWA KAROLINA A (US)
MURPHY ANDREW J (US)
Application Number:
PCT/US2012/034737
Publication Date:
March 14, 2013
Filing Date:
April 24, 2012
Export Citation:
Assignee:
REGENERON PHARMA (US)
MCWHIRTER JOHN (US)
MACDONALD LYNN (US)
STEVENS SEAN (US)
DAVIS SAMUEL (US)
BUCKLER DAVID R (US)
HOSIAWA KAROLINA A (US)
MURPHY ANDREW J (US)
MCWHIRTER JOHN (US)
MACDONALD LYNN (US)
STEVENS SEAN (US)
DAVIS SAMUEL (US)
BUCKLER DAVID R (US)
HOSIAWA KAROLINA A (US)
MURPHY ANDREW J (US)
International Classes:
A01K67/027
Attorney, Agent or Firm:
POBURSKY, Kevin, J. (Inc.777 Old Saw Mill River Roa, Tarrytown NY, US)
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