NON-HUMAN MAMMALIAN MODEL EXPRESSING IL-8 AND USE THEREOF

Title:

NON-HUMAN MAMMALIAN MODEL EXPRESSING IL-8 AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/021059

Kind Code:

A1

Abstract:

Provided is a non-human mammalian model expressing IL-8 and use thereof. Specifically, provided is a non-human mammalian model expressing IL-8. The non-human mammalian model expressing IL-8 can be better used to prepare a tumor-bearing non-human mammalian model expressing IL-8 which can be used for studying the effect of IL-8 on tumors and screening or identifying potential therapeutic agents for the prevention and/or treatment of tumors.

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Inventors:

LIU XINDONG (CN)
LIU HAOFEI (CN)
BIAN XIUWU (CN)

Application Number:

PCT/CN2022/109093

Publication Date:

February 01, 2024

Filing Date:

July 29, 2022

Export Citation:

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Assignee:

JINFENG LABORATORY (CN)

International Classes:

A01K67/027; A61K49/00; C07K16/28; G01N33/68

Foreign References:

US20210355501A1	2021-11-18
US20210054063A1	2021-02-25
US20080216182A1	2008-09-04
CN114304065A	2022-04-12
US20090285832A1	2009-11-19
US20170274073A1	2017-09-28

Other References:

ASFAHA，S. ET AL.: "Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis", GASTROENTEROLOGY, vol. 144, no. 1, 31 December 2013 (2013-12-31), pages 155 - 166, XP055091627, DOI: 10.1053/j.gastro.2012.09.057

Attorney, Agent or Firm:

SHANGHAI BESTFAMEIP INTELLECTUAL PROPERTY ATTORNEYS (CN)

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