NON-INVASIVE DIAGNOSTIC BIOMARKER FOR PANCREATIC ISLET POPULATIONS

Title:

NON-INVASIVE DIAGNOSTIC BIOMARKER FOR PANCREATIC ISLET POPULATIONS

Document Type and Number:

WIPO Patent Application WO/2019/079449

Kind Code:

A8

Abstract:

Aspects of the disclosure relate to systems and methods for obtaining and interpreting magnetic resonance spectroscopy (MRS) data obtained from the pancreas of a subject. In some embodiments, systems and methods of the disclosure relate to analyzing MRS spectra of metabolites, for example γ-Aminobutyric acid (GABA), to assess pancreatic islet density and function in a subject. In some embodiments, systems and methods described by the disclosure are useful for the diagnosis and/or treatment of diseases associated with impaired pancreatic function, for example diabetes.

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Inventors:

PORGES ERIC (US)
LAMB DAMON (US)
CAMPBELL THOMPSON (US)
EDDEN RICHARD (US)

Application Number:

PCT/US2018/056287

Publication Date:

May 23, 2019

Filing Date:

October 17, 2018

Export Citation:

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Assignee:

UNIV FLORIDA (US)
UNIV JOHNS HOPKINS (US)

International Classes:

A61K31/197; G01N24/08; G01R33/465

Attorney, Agent or Firm:

MACDONALD, Kevin (US)

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