Title:
NON-NATURAL NUCLEOSIDES AS THERANOSTIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2013/033705
Kind Code:
A3
Abstract:
A theranostic agent for inhibiting translesion DNA replication comprises natural adenine ribose analog having formula I.
Inventors:
BERDIS ANTHONY J (US)
LEE IRENE (US)
MOTEA EDWARD (US)
LEE IRENE (US)
MOTEA EDWARD (US)
Application Number:
PCT/US2012/053669
Publication Date:
June 27, 2013
Filing Date:
September 04, 2012
Export Citation:
Assignee:
UNIV CASE WESTERN RESERVE (US)
BERDIS ANTHONY J (US)
LEE IRENE (US)
MOTEA EDWARD (US)
BERDIS ANTHONY J (US)
LEE IRENE (US)
MOTEA EDWARD (US)
International Classes:
C07H19/044; A61K48/00; C07H19/14; C07H19/16; G01N33/50
Foreign References:
| US20090048202A1 | 2009-02-19 | |||
| US5401724A | 1995-03-28 | |||
| US20070259832A1 | 2007-11-08 |
Other References:
REINEKS, E. Z. ET AL.: "Evaluating the contribution of base stacking during translesion DNA replication", BIOCHEMISTRY, vol. 43, no. 2, 2004, pages 393 - 404, XP003005362
GIRGIS, N. S. ET AL.: "'Synthesis of 2'deoxyribofuranosyl indole nucleosides related to the antibiotics SF-2140 and neosidomycin'", JOURNAL OF HETERO- CYCLIC CHEMISTRY, vol. 25, no. 2, 2009, pages 361 - 366, XP008074079
MOTEA, E. A. ET AL.: "A non-natural nucleoside with combined therapeutic and diagnostic activities against leukemia", ACS CHEMICAL BIOLOGY, vol. 7, no. 6, 5 March 2012 (2012-03-05), pages 988 - 998, XP055128554
GIRGIS, N. S. ET AL.: "'Synthesis of 2'deoxyribofuranosyl indole nucleosides related to the antibiotics SF-2140 and neosidomycin'", JOURNAL OF HETERO- CYCLIC CHEMISTRY, vol. 25, no. 2, 2009, pages 361 - 366, XP008074079
MOTEA, E. A. ET AL.: "A non-natural nucleoside with combined therapeutic and diagnostic activities against leukemia", ACS CHEMICAL BIOLOGY, vol. 7, no. 6, 5 March 2012 (2012-03-05), pages 988 - 998, XP055128554
Attorney, Agent or Firm:
SUTKUS, Richard, A. (Sundheim Covell & Tummino LLP,1300 East Ninth Street Suite 170, Cleveland OH, US)
Download PDF:
Previous Patent: BRUSHLESS DC MOTOR - DRIVEN CIRCULAR SAW
Next Patent: ATOMIZING SPRAY HEADS, ATOMIZING METHODS, AND FLUID SYSTEMS OPERATING THEREWITH
Next Patent: ATOMIZING SPRAY HEADS, ATOMIZING METHODS, AND FLUID SYSTEMS OPERATING THEREWITH