Title:
NON-SMALL CELL LUNG CANCER DETECTION MARKER, DETECTION METHOD THEREOF, RELATED REAGENT KIT AND BIOCHIP
Document Type and Number:
WIPO Patent Application WO/2010/069129
Kind Code:
A1
Abstract:
The present invention provides detection markers for estimating the status of non-small cell lung cancer of the subjects, which include any combination of 26 kinds of detectable small RNA existing in the serum/plasma of the subjects steadily. Also provided are detection method thereof, related reagent kit and biochip.
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Inventors:
ZHANG CHENYU (CN)
ZENG KE (CN)
ZHANG JUNFENG (CN)
BA YI (CN)
CHEN XI (CN)
LI HAIJIN (CN)
ZENG KE (CN)
ZHANG JUNFENG (CN)
BA YI (CN)
CHEN XI (CN)
LI HAIJIN (CN)
Application Number:
PCT/CN2009/001441
Publication Date:
June 24, 2010
Filing Date:
December 14, 2009
Export Citation:
Assignee:
MICROMEDMARK BIOTECH CO LTD (CN)
ZHANG CHENYU (CN)
ZENG KE (CN)
ZHANG JUNFENG (CN)
BA YI (CN)
CHEN XI (CN)
LI HAIJIN (CN)
ZHANG CHENYU (CN)
ZENG KE (CN)
ZHANG JUNFENG (CN)
BA YI (CN)
CHEN XI (CN)
LI HAIJIN (CN)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2007081740A2 | 2007-07-19 |
Foreign References:
| CN101475984A | 2009-07-08 | |||
| CN101307361A | 2008-11-19 | |||
| CN100999765A | 2007-07-18 | |||
| CN101298630A | 2008-11-05 |
Other References:
LAWRIE CH; GAL S; DUNLOP HM ET AL.: "Detection of elevated levels of tumor-associated microRNAs in serum of patients with diffuse large B-cell lymphoma", BR J HAEMATOL, vol. 141, 2008, pages 672 - 675
GAROFALO M; QUINTAVALLE C; DI LEVA G ET AL.: "MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer", ONCOGENE, 2008
TRYNDYAK VP; ROSS SA; BELAND FA; POGRIBNY IP: "Down-regulation of the microRNAs miR-34a, miR-127 and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet", MOL CARCINOG, 21 October 2008 (2008-10-21)
CHEN ET AL.: "Characterization of microRNAs in serum: a novel class of markers for diagnosis of cancer and other diseases", CELL RES., vol. 18, no. 10, October 2008 (2008-10-01), pages 997
See also references of EP 2327800A4
GAROFALO M; QUINTAVALLE C; DI LEVA G ET AL.: "MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer", ONCOGENE, 2008
TRYNDYAK VP; ROSS SA; BELAND FA; POGRIBNY IP: "Down-regulation of the microRNAs miR-34a, miR-127 and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet", MOL CARCINOG, 21 October 2008 (2008-10-21)
CHEN ET AL.: "Characterization of microRNAs in serum: a novel class of markers for diagnosis of cancer and other diseases", CELL RES., vol. 18, no. 10, October 2008 (2008-10-01), pages 997
See also references of EP 2327800A4
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (18th FloorTower 2, Xihuan Plaza,1 Xizhimenwai Street,Xicheng District, Beijing 4, CN)
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