Title:
NON-STEROIDAL MODULATORS OF ESTROGEN RECEPTORS
Document Type and Number:
WIPO Patent Application WO2002066415
Kind Code:
A3
Abstract:
Estrogen receptor modulators, compositions comprising the compounds and methods relating to the use thereof are described. The compounds may be used in inhibiting the proliferation of and/or induces apoptosis in human breast cancer cells.
Inventors:
MEEGAN MARY JANE (IE)
HUGHES ROSARIO BRIDGET (IE)
ZISTERER DANIELA MARIA (IE)
LLOYD DAVID GEORGE (IE)
HUGHES ROSARIO BRIDGET (IE)
ZISTERER DANIELA MARIA (IE)
LLOYD DAVID GEORGE (IE)
Application Number:
PCT/IE2002/000020
Publication Date:
December 12, 2002
Filing Date:
February 20, 2002
Export Citation:
Assignee:
TRINITY COLLEGE DUBLIN (IE)
MEEGAN MARY JANE (IE)
HUGHES ROSARIO BRIDGET (IE)
ZISTERER DANIELA MARIA (IE)
LLOYD DAVID GEORGE (IE)
MEEGAN MARY JANE (IE)
HUGHES ROSARIO BRIDGET (IE)
ZISTERER DANIELA MARIA (IE)
LLOYD DAVID GEORGE (IE)
International Classes:
A61P35/00; C07C43/215; C07C43/23; C07C211/45; C07C211/48; C07C215/16; C07C217/08; C07C217/16; C07C217/18; C07C217/20; C07C217/80; C07C233/07; C07C271/16; C07D295/092; (IPC1-7): C07C217/80; A61K31/138; A61K31/395; A61K31/136; A61P35/00; C07C217/16; C07C233/07; C07C215/16; C07D295/08; C07C217/18; C07C217/20; C07C211/45; C07C43/215; C07D309/12
Foreign References:
| GB1013907A | 1965-12-22 |
Other References:
GOPALCHARI R. ET AL.: "Antifertility agents: 1,2,3-triphenylpropenes", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY., vol. 9, no. 1, 1971, pages 104 - 105, XP008008753, ISSN: 0019-5189
LLOYD D.G. ET AL.: "Recent advances in estrogen receptor antagonists", IDRUGS, vol. 3, no. 6, 2000, CURRENT DRUGS LTD, GB, pages 632 - 642, XP008008750, ISSN: 1369-7056
LERNER L.J. ET AL.: "Development of antiestrogens and their use in breast cancer: Eighth Cain Memorial Award Lecture", CANCER RESEARCH., vol. 50, 1990, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, pages 4177 - 4189, XP008008756, ISSN: 0008-5472
MEEGAN M.J. ET AL.: "Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells", JOURNAL OF MEDICINAL CHEMISTRY., vol. 44, no. 7, - 29 March 2001 (2001-03-29), AMERICAN CHEMICAL SOCIETY. WASHINGTON., US, pages 1072 - 1084, XP002215447, ISSN: 0022-2623
MEEGAN M.J. ET AL.: "Ethyl side-chain modifications in novel flexible antiestrogens-design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line", ANTI-CANCER DRUG DESIGN, vol. 16, no. 1, 2001, BASINGSTOKE, GB, pages 57 - 69, XP008008751, ISSN: 0266-9536
LLOYD D.G. ET AL.: "Recent advances in estrogen receptor antagonists", IDRUGS, vol. 3, no. 6, 2000, CURRENT DRUGS LTD, GB, pages 632 - 642, XP008008750, ISSN: 1369-7056
LERNER L.J. ET AL.: "Development of antiestrogens and their use in breast cancer: Eighth Cain Memorial Award Lecture", CANCER RESEARCH., vol. 50, 1990, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, pages 4177 - 4189, XP008008756, ISSN: 0008-5472
MEEGAN M.J. ET AL.: "Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells", JOURNAL OF MEDICINAL CHEMISTRY., vol. 44, no. 7, - 29 March 2001 (2001-03-29), AMERICAN CHEMICAL SOCIETY. WASHINGTON., US, pages 1072 - 1084, XP002215447, ISSN: 0022-2623
MEEGAN M.J. ET AL.: "Ethyl side-chain modifications in novel flexible antiestrogens-design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line", ANTI-CANCER DRUG DESIGN, vol. 16, no. 1, 2001, BASINGSTOKE, GB, pages 57 - 69, XP008008751, ISSN: 0266-9536
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