Title:
NONHUMAN ANIMAL HAVING EXPRESSION OF BACH2 ARTIFICIALLY INHIBITED, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/110433
Kind Code:
A1
Abstract:
A bach2 gene knockout mouse was prepared and analyzed. As a result, it has been found that the bach2 gene knockout mouse develops inflammatory enteropathy and hyper-IgM syndrome and that therein, the amount of IgM in serum is increased over that of controls not having the expression of bach2 gene artificially inhibited.
Inventors:
IGARASHI KAZUHIKO (JP)
MUTO TETSUHIKO (JP)
YAMAMOTO MASAYUKI (JP)
MUTO TETSUHIKO (JP)
YAMAMOTO MASAYUKI (JP)
Application Number:
PCT/JP2005/008928
Publication Date:
November 24, 2005
Filing Date:
May 17, 2005
Export Citation:
Assignee:
IGARASHI KAZUHIKO (JP)
MUTO TETSUHIKO (JP)
YAMAMOTO MASAYUKI (JP)
MUTO TETSUHIKO (JP)
YAMAMOTO MASAYUKI (JP)
International Classes:
A01K67/027; A61K31/711; A61K48/00; C07K16/00; C12N5/10; C12Q1/68; G01N33/15; G01N33/50; G01N33/68; (IPC1-7): A61K31/711; A01K67/027; A61K48/00; C07K16/00; C12N5/10; C12Q1/68; G01N33/15; G01N33/50
Other References:
SASAKI S. ET AL.: "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6p15.", ONCOGENE, vol. 19, 2000, pages 3739 - 3749, XP002978355
HOSHINO H. ET AL.: "Oxidative stress abolished leptomycin B-sencitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element.", J.BIOL.CHEM., vol. 275, no. 20, 2000, pages 15370 - 15376, XP002990361
KOBAYASHI A. ET AL.: "A Combinatorial code for gene expression generated by transcription factor Bach2 and Mazr (MAZ-Related Factor) htrough th BTB/POZ domein.", MOL.CELL.BIOL., vol. 20, no. 5, 2000, pages 1733 - 1746, XP002166352
OYAKE T. ET AL.: "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with Mafk and regulate transcription through the NF-E2 site.", MOL.CELL.BIOL., vol. 16, no. 11, 1996, pages 6083 - 6095, XP002990362
HOSHINO H. ET AL.: "Oxidative stress abolished leptomycin B-sencitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element.", J.BIOL.CHEM., vol. 275, no. 20, 2000, pages 15370 - 15376, XP002990361
KOBAYASHI A. ET AL.: "A Combinatorial code for gene expression generated by transcription factor Bach2 and Mazr (MAZ-Related Factor) htrough th BTB/POZ domein.", MOL.CELL.BIOL., vol. 20, no. 5, 2000, pages 1733 - 1746, XP002166352
OYAKE T. ET AL.: "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with Mafk and regulate transcription through the NF-E2 site.", MOL.CELL.BIOL., vol. 16, no. 11, 1996, pages 6083 - 6095, XP002990362
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)
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