Title:
NONINVASIVE ANALYSIS METHOD
Document Type and Number:
WIPO Patent Application WO/2006/106752
Kind Code:
A1
Abstract:
A method whereby a biological process in a mammalian subject is more effectively analyzed or measured with the use of noninvasive imaging. More specifically speaking, a method of conducting more effective optical noninvasive imaging by using a luminescent enzyme which exhibits a luminescent activity in the long wavelength side with a high tissue permeability and shows little change in the luminescent spectrum depending on pH.
Inventors:
ASAI TOMOMI (JP)
NISHII SHIGEAKI (JP)
SHIMIZU RITSUKO (JP)
YAMAMOTO MASAYUKI (JP)
OHMIYA YOSHIHIRO (JP)
NISHII SHIGEAKI (JP)
SHIMIZU RITSUKO (JP)
YAMAMOTO MASAYUKI (JP)
OHMIYA YOSHIHIRO (JP)
Application Number:
PCT/JP2006/306506
Publication Date:
October 12, 2006
Filing Date:
March 29, 2006
Export Citation:
Assignee:
TOYO BOSEKI (JP)
NAT INST OF ADVANCED IND SCIEN (JP)
ASAI TOMOMI (JP)
NISHII SHIGEAKI (JP)
SHIMIZU RITSUKO (JP)
YAMAMOTO MASAYUKI (JP)
OHMIYA YOSHIHIRO (JP)
NAT INST OF ADVANCED IND SCIEN (JP)
ASAI TOMOMI (JP)
NISHII SHIGEAKI (JP)
SHIMIZU RITSUKO (JP)
YAMAMOTO MASAYUKI (JP)
OHMIYA YOSHIHIRO (JP)
International Classes:
A61K49/00; A01K67/00; A01K67/027; A61B10/00; C12N5/10; G01N21/76; G01N33/483
Domestic Patent References:
| WO2003016839A2 | 2003-02-27 |
Foreign References:
| US20020119542A1 | 2002-08-29 |
Other References:
NAKAJIMA Y. ET AL.: "Improved expression of novel red- and green-emitting luciferase of Phrixothrix railroad worms in mammalian cells", BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 68, no. 4, 2004, pages 948 - 951, XP003002802
RICE B.W. ET AL.: "In vivo imaging of light-emitting probes", JOURNAL OF BIOMEDICAL OPTICS, vol. 6, no. 4, 2001, pages 432 - 440, XP003002803
TROY T. ET AL.: "Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models", MOLECULAR IMAGING, vol. 3, no. 1, 2004, pages 9 - 23, XP009049182
ZHANG W. ET AL.: "A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene", DRUG METABOLISM AND DISPOSITION, vol. 31, no. 8, 2003, pages 1054 - 1064, XP003002804
MALSTROM S.E. ET AL.: "The characterization and hormonal regulation of kidney androgen-regulated protein (Kap)-luciferase transgenic mice", TOXICOLOGICAL SCIENCES, vol. 79, no. 2, 2004, pages 266 - 277, XP003002805
KIM D.E. ET AL.: "Imaging of stem cell recruitment to ischemic infarcts in a murine model", STROKE, vol. 35, no. 4, 2004, pages 952 - 957, XP003002806
WANG X. ET AL.: "Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging", BLOOD, vol. 102, no. 10, 2003, pages 3478 - 3482, XP003002807
AINSCOW E.K.: "Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels", THE JOURNAL OF PHYSIOLOGY, vol. 544, 2002, pages 429 - 445, XP003002808
BUTTIGIEG J. ET AL.: "Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 322, no. 1, 2004, pages 82 - 87, XP004526703
RICE B.W. ET AL.: "In vivo imaging of light-emitting probes", JOURNAL OF BIOMEDICAL OPTICS, vol. 6, no. 4, 2001, pages 432 - 440, XP003002803
TROY T. ET AL.: "Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models", MOLECULAR IMAGING, vol. 3, no. 1, 2004, pages 9 - 23, XP009049182
ZHANG W. ET AL.: "A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene", DRUG METABOLISM AND DISPOSITION, vol. 31, no. 8, 2003, pages 1054 - 1064, XP003002804
MALSTROM S.E. ET AL.: "The characterization and hormonal regulation of kidney androgen-regulated protein (Kap)-luciferase transgenic mice", TOXICOLOGICAL SCIENCES, vol. 79, no. 2, 2004, pages 266 - 277, XP003002805
KIM D.E. ET AL.: "Imaging of stem cell recruitment to ischemic infarcts in a murine model", STROKE, vol. 35, no. 4, 2004, pages 952 - 957, XP003002806
WANG X. ET AL.: "Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging", BLOOD, vol. 102, no. 10, 2003, pages 3478 - 3482, XP003002807
AINSCOW E.K.: "Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels", THE JOURNAL OF PHYSIOLOGY, vol. 544, 2002, pages 429 - 445, XP003002808
BUTTIGIEG J. ET AL.: "Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 322, no. 1, 2004, pages 82 - 87, XP004526703
Attorney, Agent or Firm:
Saegusa, Eiji (1-7-1, Doshomachi, Chuo-ku, Osaka-shi Osaka 45, JP)
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