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Title:
NONSTEROIC ANDROGEN ACCEPTOR REGULATORS, PREPARATION PROCESS, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/125397
Kind Code:
A1
Abstract:
Nonsteroic androgen acceptor regulator compounds of the general formula (I), pharmaceutically acceptable salts thereof, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or pharmaceutically acceptable salts thereof can be used for preparing nonsteroic medicines to treat and/or prevent conditions or diseases such as prostatic hyperplasi, prostatic cancer, hirsutism, high hormone-dependent alopecia and cane et al. because of androgen acceptor antagonistic activity.

Inventors:
Wang, Mingwei (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Deng, Yong (24 South Section 1, Yihuan Road Chengdu, Sichuan 5, 61006, CN)
Zhou, Caihong (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Yang, Dacheng (24 South Section 1, Yihuan Road Chengdu, Sichuan 5, 61006, CN)
Hui, Xin (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Haoran SU. (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Gao, Jie (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Application Number:
PCT/CN2006/001106
Publication Date:
November 30, 2006
Filing Date:
May 26, 2006
Export Citation:
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Assignee:
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
SICHUAN UNIVERSITY (24 South Section 1, Yihuan Road Chengdu, Sichuan 5, 61006, CN)
Wang, Mingwei (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Deng, Yong (24 South Section 1, Yihuan Road Chengdu, Sichuan 5, 61006, CN)
Zhou, Caihong (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Yang, Dacheng (24 South Section 1, Yihuan Road Chengdu, Sichuan 5, 61006, CN)
Hui, Xin (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Haoran SU. (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
Gao, Jie (No. 555, Zuchongzhi Road Pudong New District, Shanghai 3, 20120, CN)
International Classes:
C07C225/22; A61K31/341; A61K31/44; C07C221/00; C07C227/00; C07C229/60; C07D211/06; C07D307/52
Domestic Patent References:
WO2004112690A2
Foreign References:
US4277474A
CN1199731A
CN1292792A
JP2003154275A
JPH115771A
JPS3928322B1
JPS4330298B1
DE1617683B
SU162127A
SU164614A
Other References:
BAOYOU L. ET AL.: 'Mannich Reaction of Aldehydes, Ketones and Amines Catalyzed by Bronsted acid Ionic liquids' JOURNAL OF CHEMICAL INDUSTRY AND ENGINEERING vol. 55, no. 12, 2004, pages 2043 - 2046, XP008073889
JUNHUA Z.: 'The Mannich Reaction Between 3-Nitrobenzaldehyde(3-Chlorobenzaldehyde), Aromatic Amines and Aromatic Ketones' ORGANIC CHEMISTRY vol. 16, 1996, pages 218 - 222, XP008073894
LIN Y. ET AL.: 'The Mannich Reactions Between Aromatic Ketones, Aromatic Aldehydes and Aromatic Amines' SYNTHESIS vol. 9, 1991, pages 717 - 718, XP003004278
JUNHUA Z. ET AL.: 'The Mannich Reaction among Acetophenone, p-Methoxybenzaldehyde and Aryiamines' JOURNAL OF SOUTHWEST CHINA NORMAL UNIVERSITY vol. 16, no. 1, 1991, pages 66 - 70, XP008133415
AKIYAMA T. ET AL.: 'HCI-Catalyzed Stereoselective Mannich Reaction In H2O-SDS System' LETTER no. 2, 2005, pages 322 - 324, XP003004279
DACHENG Y. ET AL.: 'The Mannich Reaction of 4-Methylacetophenone with Aromatic Aldehydes and aromatic Amines' CHEMICAL JOURNAL OF CHINESE UNIVERSITIES vol. 21, no. 11, 2000, pages 1694 - 1696, XP008073888
See also references of EP 1889829A1
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (11/F, Block B KingSound Internation Center, 116 Zizhuyuan Roa, Haidian District Beijing 9, 10008, CN)
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