Title:
NONVIRAL GENE TRANSFER TO THE SUPRACHOROIDAL SPACE
Document Type and Number:
WIPO Patent Application WO/2019/070727
Kind Code:
A3
Abstract:
The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.
Inventors:
CAMPOCHIARO PETER A (US)
GREEN JORDAN (US)
KIM JAYOUNG (US)
SHEN JIKUI (US)
GREEN JORDAN (US)
KIM JAYOUNG (US)
SHEN JIKUI (US)
Application Number:
PCT/US2018/053990
Publication Date:
May 31, 2019
Filing Date:
October 02, 2018
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
A61K48/00; A61K9/16; A61K9/51; A61P27/02
Domestic Patent References:
| WO2016042163A2 | 2016-03-24 |
Foreign References:
| US20120128782A1 | 2012-05-24 | |||
| US20150273071A1 | 2015-10-01 | |||
| US20160101054A1 | 2016-04-14 |
Other References:
SHMUELI, R. B. ET AL.: "Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide", BIOMATERIALS, vol. 34, 2013, pages 7544 - 7551, XP028679370, DOI: 10.1016/j.biomaterials.2013.06.044
BHISE, N. S. ET AL.: "Evaluating the potential of poly (beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 8, 3 December 2013 (2013-12-03), pages 4641 - 4658, XP055616136, DOI: 10.2147/IJN.S53830
SUNSHINE, J. C. ET AL.: "Poly (beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo", PLOS ONE, vol. 7, no. 5, 2012, pages 1 - 11, XP002746169, DOI: 10.1371/journal.pone.0037543
BHISE, N. S. ET AL.: "Evaluating the potential of poly (beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 8, 3 December 2013 (2013-12-03), pages 4641 - 4658, XP055616136, DOI: 10.2147/IJN.S53830
SUNSHINE, J. C. ET AL.: "Poly (beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo", PLOS ONE, vol. 7, no. 5, 2012, pages 1 - 11, XP002746169, DOI: 10.1371/journal.pone.0037543
Attorney, Agent or Firm:
CHILDERS, Jeffrey W. (US)
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