NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLCHALCOGENO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS

Title:

NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLCHALCOGENO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS

Document Type and Number:

WIPO Patent Application WO/2008/059865

Kind Code:

A1

Abstract:

Disclosed is a novel 1,2-dihydroquinoline derivative represented by the general formula (1) below, which has a substituted phenylchalcogeno lower alkyl group and a phenyl group having an ester structure introduced therein as substituents, or a salt of such a derivative. The compound (1) or a salt thereof is useful as a glucocorticoid receptor modulator. In the formula below, R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or a nitro group; X represents -C(O)-, -C(O)NR8-, -S(O)2- or the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted lower alkoxy group or the like; Y represents a lower alkylene group; Z represent a chalcogen atom; and p represents 0, 1, 2 or 3.

Inventors:

MATSUDA MAMORU (JP)
NAGATSUKA MASATO (JP)
MORI TOSHIYUKI (JP)
KOBAYASHI SACHIKO (JP)
KATO MASATOMO (JP)
TAKAI MIWA (JP)

Application Number:

PCT/JP2007/072081

Publication Date:

May 22, 2008

Filing Date:

November 14, 2007

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Assignee:

SANTEN PHARMACEUTICAL CO LTD (JP)
MATSUDA MAMORU (JP)
NAGATSUKA MASATO (JP)
MORI TOSHIYUKI (JP)
KOBAYASHI SACHIKO (JP)
KATO MASATOMO (JP)
TAKAI MIWA (JP)

International Classes:

C07D215/14; A61K31/47; A61K31/4709; A61P1/04; A61P3/04; A61P3/06; A61P3/10; A61P3/14; A61P5/00; A61P9/00; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P25/00; A61P25/18; A61P25/28; A61P27/06; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D311/80; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D491/052

Domestic Patent References:

WO2007032556A1	2007-03-22
WO2006019716A1	2006-02-23
WO2004018429A2	2004-03-04
WO2006019716A1	2006-02-23

Foreign References:

JPH10510840A	1998-10-20
JP2006504678A	2006-02-09
JP2002193955A	2002-07-10
JPH10510840A	1998-10-20

Other References:

SOUGOU RINSYOU, vol. 54, no. 7, 2005, pages 1951 - 2076
See also references of EP 2085387A4

Attorney, Agent or Firm:

HIBI, Norihiko et al. (3rd Floor Inaba Building, 13-18, Nishishinsaibashi 1-chome, Chuo-ku, Osaka-sh, Osaka 86, JP)

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