NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP

WIPO Patent Application WO/1996/014293

A1

A compound represented by general formula (I) and salts thereof, wherein R1 and R4 represent carboxyl optionally converted into an ester, amide or hydroxamate group; R2 represents lower alkyl or phenyl lower alkyl; and R3 represents hydrogen, lower alkyl, amino lower alkyl, lower alkylamino lower alkyl, hydroxy lower alkyl, mercapto lower alkyl, carboxy lower alkyl, lower alkoxycarbonyl lower alkyl, imidazolyl lower alkyl, indolyl lower alkyl, optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted naphthyl or optionally substituted naphthyl lower alkyl. The compound has an inhibitory effect on endopeptidase 24.11 and being useful as a remedy for cardiovascular diseases such as cardiac insufficiency and hypertension, kidney diseases such as renal insufficiency, gastrointestinal disorders such as diarrhea and gastric hyperacidity, endocrine/metabolic diseases such as obesity, and autoimmune diseases such as rheumatism, and as an analgesic agent for muscular pain, hemicrania, etc.

KAWASHIMA YOICHI (JP)
FUJIMURA KEN-ICHI (JP)
SUHARA HIROSHI (JP)
MIYAWAKI NOBUAKI (JP)
FUJITA YUKO (JP)

PCT/JP1995/002236

May 17, 1996

November 01, 1995

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SANTEN PHARMACEUTICAL CO LTD (JP)
KAWASHIMA YOICHI (JP)
FUJIMURA KEN ICHI (JP)
SUHARA HIROSHI (JP)
MIYAWAKI NOBUAKI (JP)
FUJITA YUKO (JP)

C07C275/24; C07D233/64; (IPC1-7): C07C275/10; C07C275/24; C07D233/64; C07D209/00; A61K31/415; A61K31/22; A61K31/17

JPS5832851A	1983-02-25
JPS62292753A	1987-12-19

PAVEL MAJER, JOURNAL OF ORGANIC CHEMISTRY, Vol. 59, No. 7, (April: 1994), p. 1937-1938.
See also references of EP 0738711A4

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