NOVEL 1,3-DIALKYLUREA DERIVATIVES - SANTEN PHARMACEUTICAL CO LTD

Title:

NOVEL 1,3-DIALKYLUREA DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1996/018606

Kind Code:

A1

Abstract:

A compound represented by general formula (I) and salts thereof, wherein R1 and R5 represent each carboxyl, sulfo or a derivative thereof; R2 represents hydrogen, lower alkyl, (substituted) phenyl-lower alkyl, lower alkoxy or (substituted) phenyl-lower alkoxy; R3 represents lower alkyl or (substituted) phenyl-lower alkyl; and R4 represents a group represented by general formula (XI), (XII) or (XIII). The compound has an endopeptidase 24.11 inhibitory activity and is useful for treating cardiovascular diseases such as cardiac failure and hypertension, kidney diseases such as renal failure, gastrointestinal disorders such as diarrhea and gastric hyperacidity, endocrine-metabolic diseases such as obesity, and autoimmune diseases such as rheumatism, and for mitigating muscular pain and migraine.

Inventors:

KAWASHIMA YOICHI (JP)
FUJIMURA KEN-ICHI (JP)
SUHARA HIROSHI (JP)
YAMAMOTO NORIYOSHI (JP)
MATSUMOTO HIROMI (JP)
MIYAWAKI NOBUAKI (JP)
FUJITA YUKO (JP)

Application Number:

PCT/JP1995/002539

Publication Date:

June 20, 1996

Filing Date:

December 11, 1995

Export Citation:

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Assignee:

SANTEN PHARMACEUTICAL CO LTD (JP)
KAWASHIMA YOICHI (JP)
FUJIMURA KEN ICHI (JP)
SUHARA HIROSHI (JP)
YAMAMOTO NORIYOSHI (JP)
MATSUMOTO HIROMI (JP)
MIYAWAKI NOBUAKI (JP)
FUJITA YUKO (JP)

International Classes:

C07C275/24; C07F9/38; C07F9/40; (IPC1-7): C07C275/18; C07F9/09; A61K31/17; A61K31/195; A61K31/215; A61K31/175; A61K31/66

Foreign References:

JPS5855451A	1983-04-01
JPS6140252A	1986-02-26
US5262178A	1993-11-16
JPS535119A	1978-01-18

Other References: