Title:
NOVEL 3-(ISOXAZOL-3-YL)-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE COMPOUND, WHICH IS RET KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/026718
Kind Code:
A1
Abstract:
The present invention relates to a novel 3-(isoxazol-3-yl)-pyrazolo[3,4-d]pyrimidin-4-amine compound, a preparation method for the compound, and a pharmaceutical use of the compound to be used in the prevention and treatment of various cancer diseases caused by the activity of RET kinases.
Inventors:
SIM TAE BO (KR)
YOON HO JONG (KR)
KWAK YEON UI (KR)
HUR WOO YOUNG (KR)
YOON HO JONG (KR)
KWAK YEON UI (KR)
HUR WOO YOUNG (KR)
Application Number:
PCT/KR2016/008427
Publication Date:
February 16, 2017
Filing Date:
August 01, 2016
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
C07D487/04; A61K31/42; A61K31/519; C07D413/04
Domestic Patent References:
| WO2013010136A2 | 2013-01-17 | |||
| WO2014047662A2 | 2014-03-27 |
Foreign References:
| US20100004235A1 | 2010-01-07 |
Other References:
DINER, P. ET AL.: "Preparation of 3-substituted-1-isopropyl-1 H-pyrazolo [3,4-d] Pyrimidin-4-amines as RET Kinase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 10, 2012, pages 4872 - 4876, XP055363610
YOON, H. ET AL.: "A Pyrazolo [3, 4-d] Pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 1, 10 December 2015 (2015-12-10), pages 358 - 373, XP055363611
YOON, H. ET AL.: "A Pyrazolo [3, 4-d] Pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 1, 10 December 2015 (2015-12-10), pages 358 - 373, XP055363611
Attorney, Agent or Firm:
HALLA PATENT&LAW FIRM (KR)
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