Title:
NOVEL 4-BENZYLOXYPHENYL DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/032883
Kind Code:
A1
Abstract:
A 4-benzyloxyphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: (I) wherein R¿1? and R¿2? are the same or different and each represents hydrogen, halogeno, nitro, cyano, or lower alkyl and R¿3? represents a structure represented by (II) or (III) (wherein R¿4? represents hydrogen, hydroxyalkyl, phenyl substituted by amino, or aminoalkyl; R¿5? represents hydrogen or lower alkyl; R¿6? represents hydrogen or lower alkyl; n is an integer of 0 to 3; and m is an integer of 0 or 1), provided that when R¿3? is a group containing a piperazine ring and n is 0, then at least one of R¿1? and R¿2? is halogeno, nitro, cyano, or lower alkyl. They are useful as an Na?+¿/Ca?2+¿ exchange inhibitor.
Inventors:
OGATA KAZUMI (JP)
ITO KAZUHIKO (JP)
SAKAUE TAKAHIRO (JP)
INOUE YUTAKA (JP)
ITO KAZUHIKO (JP)
SAKAUE TAKAHIRO (JP)
INOUE YUTAKA (JP)
Application Number:
PCT/JP2001/009128
Publication Date:
April 25, 2002
Filing Date:
October 17, 2001
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
OGATA KAZUMI (JP)
ITO KAZUHIKO (JP)
SAKAUE TAKAHIRO (JP)
INOUE YUTAKA (JP)
OGATA KAZUMI (JP)
ITO KAZUHIKO (JP)
SAKAUE TAKAHIRO (JP)
INOUE YUTAKA (JP)
International Classes:
A61P3/10; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P13/12; A61P27/02; A61P27/06; A61P43/00; C07D277/06; C07D295/096; (IPC1-7): C07D241/04; A61K31/426; A61K31/495; A61P3/10; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P13/12; A61P27/02; A61P27/06; A61P43/00; C07D277/04; C07D295/08; C07D295/12
Foreign References:
| JPH10245336A | 1998-09-14 |
Attorney, Agent or Firm:
Matsuda, Reiko (LTD. Intellectual Property 5-8 Hiranomachi 2-chom, Chuo-ku Osaka-shi Osaka, JP)
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