Title:
NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES
Document Type and Number:
WIPO Patent Application WO/2010/121576
Kind Code:
A3
Abstract:
The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions. ˙
Inventors:
BOURDERIOUX AURELIE (FR)
HOCEK MICHAL (CZ)
NAUS PETR (CZ)
HOCEK MICHAL (CZ)
NAUS PETR (CZ)
Application Number:
PCT/CZ2010/000050
Publication Date:
June 16, 2011
Filing Date:
April 19, 2010
Export Citation:
Assignee:
ACAD OF SCIENCE CZECH REPUBLIC (CZ)
BOURDERIOUX AURELIE (FR)
HOCEK MICHAL (CZ)
NAUS PETR (CZ)
BOURDERIOUX AURELIE (FR)
HOCEK MICHAL (CZ)
NAUS PETR (CZ)
International Classes:
A61K31/7064; C07H19/23; A61P35/00
Domestic Patent References:
| WO2005044835A1 | 2005-05-19 | |||
| WO2010026153A1 | 2010-03-11 |
Foreign References:
| US20060079468A1 | 2006-04-13 |
Other References:
SCHRAM KARL H ET AL: "Pyrrolopyrimidine nucleosides. VIII. Synthesis of sangivamycin derivatives possessing exocyclic heterocycles at C5", JOURNAL OF CARBOHYDRATES. NUCLEOSIDES NUCLEOTIDES, MARCEL DEKKER, BASEL, CH, vol. 1, no. 1, 1 January 1974 (1974-01-01), pages 39 - 54, XP009125160, ISSN: 0094-0585
ZHANG, L. ET AL.: "Study on the synthesis and PKA-I binding activities of 5-alkynyl tubercidin analogues", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 907 - 912, XP002623437
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; L. ZHANG ET AL.: "Studies on synthesis of derivatives of 7-deaza-adenosine and their biological activities", XP002623432, retrieved from STN Database accession no. 142:366727
SEELA ET AL: "7-Functionalized 7-deazapurine beta-d and beta-l-ribonucleosides related to tubercidin and 7-deazainosine: glycosylation of pyrrolo[2,3-d]pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-d or beta-l-ribofuranose", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 63, no. 39, 16 August 2007 (2007-08-16), pages 9850 - 9861, XP022201077, ISSN: 0040-4020, DOI: DOI:10.1016/J.TET.2007.06.107
ZHANG, L. ET AL.: "Study on the synthesis and PKA-I binding activities of 5-alkynyl tubercidin analogues", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 907 - 912, XP002623437
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; L. ZHANG ET AL.: "Studies on synthesis of derivatives of 7-deaza-adenosine and their biological activities", XP002623432, retrieved from STN Database accession no. 142:366727
SEELA ET AL: "7-Functionalized 7-deazapurine beta-d and beta-l-ribonucleosides related to tubercidin and 7-deazainosine: glycosylation of pyrrolo[2,3-d]pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-d or beta-l-ribofuranose", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 63, no. 39, 16 August 2007 (2007-08-16), pages 9850 - 9861, XP022201077, ISSN: 0040-4020, DOI: DOI:10.1016/J.TET.2007.06.107
Attorney, Agent or Firm:
GABRIELOVA, Marta (Na Belidle 3, Praha 5, CZ)
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