NOVEL 8-(2-AMINOALKOXY)FLUOROCHROMAN DERIVATIVE

WIPO Patent Application WO/1994/029293

A1

An 8-(2-aminoalkoxy)fluorochroman derivative represented by general formula (I) or a salt thereof, both having a selective affinity for 5-HT1A receptors and being useful for treating psychoneurotic diseases such as anxiety, manic-depressive state and schizophrenia, sex disorder, eating disorder, sleep disorder, and drug dependence: wherein R, R2 and R3 represent each lower alkoxy, etc., or R1 and R2 may be combined together to represent -O-(CH2)m-O- (wherein m is an integer of 1 to 3), etc.; R4 represents hydrogen, lower alkyl or aralkyl; R5 represent hydroxy, amino or lower alkoxy; R6 represents hydrogen or lower alkyl, provided R5, R6 and the carbon atom to which they are bonded are combined together to represent carbonyl; A represents an ethylene group which may be substituted by lower alkyl; and B represents optionally branched C1-C10 alkylene.

YASUNAGA TOMOYUKI (JP)
KIMURA TAKENORI (JP)
NAITO RYO (JP)
KONTANI TORU (JP)
YAMAGUCHI TOKIO (JP)
WANIBUCHI FUMIKAZU (JP)

PCT/JP1994/000923

December 22, 1994

June 08, 1994

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YAMANOUCHI PHARMA CO LTD (JP)
YASUNAGA TOMOYUKI (JP)
KIMURA TAKENORI (JP)
NAITO RYO (JP)
KONTANI TORU (JP)
YAMAGUCHI TOKIO (JP)
WANIBUCHI FUMIKAZU (JP)

C07D311/22; C07D407/12; (IPC1-7): C07D311/22; A61K31/35; A61K31/36; C07D311/68; C07D407/12

JPH05255302A	1993-10-05
JPH05125024A	1993-05-21
JPS4729367A

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