Title:
NOVEL ACYLATING REAGENTS
Document Type and Number:
WIPO Patent Application WO2004043884
Kind Code:
A3
Abstract:
Novel acylating agents useful for preparing activated nucleophiles such as terminally activated polymers are disclosed. In preferred aspects, the acylating agents are formula (I) and formula (II) and they used to prepare activated polymers such as PEG's for conjugating small molecules, proteins, polypeptides and the like.
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Inventors:
ZHAO HONG
GREENWALD RICHARD B
GREENWALD RICHARD B
Application Number:
PCT/US2003/035742
Publication Date:
September 23, 2004
Filing Date:
November 11, 2003
Export Citation:
Assignee:
ENZON PHARMACEUTICALS INC (US)
International Classes:
C07C69/96; C07C205/43; C07C251/24; C07C329/02; C07D207/404; C07D309/12; C07D309/14; C07D405/04; C07F7/18; C08G65/331; C07D207/40; (IPC1-7): C07C69/76
Other References:
YOKOZAWA ET AL: "Reductive Polycondensation. Synthesis of Polyethers consisting of one unit from Dialdehydes and of Polyethers consisting of two alternating units from Dialdehydes and Alkylene Bis(trimethylsilyl) Ethers 1", MACROMOLECULES, vol. 28, 1995, pages 4668 - 4674, XP000512306
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