Title:
NOVEL ADAPTOR PROTEIN BINDING TO MAMMALIAN TOLL-LIKE RECEPTOR 3 AND GENE THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/050868
Kind Code:
A1
Abstract:
It is intended to provide a novel adaptor protein efficacious in preventing and treating viral infections such as hepatitis B and hepatitis C and treating tumor, etc. which controls the production of I-type interferon and binds to mammalian Toll-like receptor 3, and its gene. A novel adaptor protein TICAM-1 comprising an amino acid sequence represented by SEQ ID NO:2 or 4, binding specifically to mammalian Toll-like receptor 3 and inducing the production of I-type interferon. A mutant of the above adaptor protein TICAM-1 has the same properties, so long as it carries a TIR domain (an amino acid sequences ranging from the 394-position to the 532-position in the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequences ranging from the 396-position to the 534-position in the amino acid sequence represented by SEQ ID NO:4). A gene encoding the above adaptor protein TICAM-1.
Inventors:
SEYA TSUKASA (JP)
MATSUMOTO MISAKO (JP)
OSHIUMI HIROYUKI (JP)
MATSUMOTO MISAKO (JP)
OSHIUMI HIROYUKI (JP)
Application Number:
PCT/JP2003/014854
Publication Date:
June 17, 2004
Filing Date:
November 20, 2003
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
SEYA TSUKASA (JP)
MATSUMOTO MISAKO (JP)
OSHIUMI HIROYUKI (JP)
SEYA TSUKASA (JP)
MATSUMOTO MISAKO (JP)
OSHIUMI HIROYUKI (JP)
International Classes:
C12N15/09; A61K38/00; A61K39/395; A61P17/00; A61P31/12; A61P35/00; A61P37/02; A61P37/08; C07K14/47; C07K16/18; C12P21/08; (IPC1-7): C12N15/09; A61K38/17; A61K39/395; A61K48/00; A61P31/12; A61P35/00; A61P37/08; C07K14/47; C07K16/18; C12N5/10; C12P21/08
Domestic Patent References:
| WO2002053737A1 | 2002-07-11 | |||
| WO2002053737A1 | 2002-07-11 |
Other References:
OSHIUMI H, ET AL: "TICAM-1, AN ADAPTOR MOLECULE THAT PARTICIPATES IN TOLL-LIKE RECEPTOR 3-MEDIATED INTERFERON-BETA INDUCTION", NAT. IMMUNOL., vol. 4, no. 2, February 2003 (2003-02-01), pages 161 - 167, XP002974653
ALEXOPOULOU L, ET AL: "RECOGNITION OF DOUBLE-STRANDED RNA AND ACTIVATION OF NF-KAPPAB BY TOLL-LIKE RECEPTOR 3", NATURE, vol. 413, no. 6857, 2001, pages 732 - 738, XP002968529
See also references of EP 1577383A4
KURT-JONES E. ET AL., JOURNAL OF ENDOCRINE RESEARCH, vol. 10, no. 6, 2004, pages 419 - 424
HASHIMOTO-GOTOH, GENE, vol. 152, 1995, pages 271 - 275
ALEXOPOULOU L, ET AL: "RECOGNITION OF DOUBLE-STRANDED RNA AND ACTIVATION OF NF-KAPPAB BY TOLL-LIKE RECEPTOR 3", NATURE, vol. 413, no. 6857, 2001, pages 732 - 738, XP002968529
See also references of EP 1577383A4
KURT-JONES E. ET AL., JOURNAL OF ENDOCRINE RESEARCH, vol. 10, no. 6, 2004, pages 419 - 424
HASHIMOTO-GOTOH, GENE, vol. 152, 1995, pages 271 - 275
Attorney, Agent or Firm:
Hara, Kenzo (Daiwa Minamimorimachi Building 2-6,
Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, JP)
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