Title:
NOVEL ADP-RIBOSYL CYCLASE AND INHIBITOR THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/262983
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising an inhibitor against the expression or activation of novel ADP-ribosyl cyclase or a naturally occurring mutant thereof as an active ingredient for preventing or treating an ADP-ribosyl cyclase-mediated disease. In addition, the present invention relates to a composition for diagnosis of an ADP-ribosyl cyclase-mediated disease, the composition comprising an agent for measuring a gene expression level or protein level of the ADP-ribosyl cyclase or a naturally occurring mutant thereof. The composition of the present invention has the effect of inhibiting the calcium increase in splenocytes, which is attributed to angiotensin II-induced ADP-ribosyl cyclase expression or activation, and as such can be advantageously used as a therapeutic agent for ADP-ribosyl cyclase-mediated diseases, particularly a renal disease.
Inventors:
KIM UH-HYUN (KR)
NAM TAE-SIK (KR)
NAM TAE-SIK (KR)
Application Number:
PCT/KR2020/008283
Publication Date:
December 30, 2020
Filing Date:
June 25, 2020
Export Citation:
Assignee:
NAT UNIV CHONBUK IND COOP FOUND (KR)
International Classes:
C12N9/10; A61P13/12; C12Q1/6883
Foreign References:
| KR20080061431A | 2008-07-03 |
Other References:
WOOHYUN KIM; PARK KWANG-HYUN; KIM SUN-YOUNG: "Development of small-molecule lead compound targeted to A DP-ribosyl cyclase for treatment of nephropathy", FINAL REPORT OF GOVERNMENT PROJECT, pages 1 - 108, XP009525356
DATABASE Genkbank ANONYMOUS: "ATPase, Na+/K+ transporting, beta 1 polypeptide [Mus musculus]", XP055770749, retrieved from Proteins Database accession no. AAH27319.1
WOOHYUN KIM: "Development of Tissue-Specific Calcium Signal Blocker Technology", GOVERNMENT PROJECT FINAL REPORT, May 2012 (2012-05-01), pages 1 - 111, XP009525357
SEON-YOUNG KIM, PARK KWANG-HYUN, GUL RUKHSANA, JANG KYU YOON, KIM UH-HYUN: "Role of kidney ADP-ribosyl cyclase in diabetic nephropathy", AMERICAN JOURNAL OF PHYSIOLOGY: RENAL PHYSIOLOGY, 1 February 2009 (2009-02-01), pages F291 - F297, XP055770728, ISSN: 1931-857X, DOI: 10.1152/ajprenal.90381.2008
BERRIDGE MJBOOTMAN MDRODERICK HL: "Calcium signaling: dynamics, homeostasis and remodeling", NAT REV MOL CELL BIOL, vol. 4, 2003, pages 517 - 529
LEE HC, MOL. MED., vol. 12, 2006, pages 317 - 323
RESNICK LM: "Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of ''Syndrome X", AM. J. HYPERTENS., vol. 6, 1993, pages 123S - 134S
COWLEY AW, JR. PHYSIOL REV., vol. 72, 1992, pages 231 - 300
KIM BJPARK KHYIM CYTAKASAWA SOKAMOTO HIM MJKIM UH: "Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets", DIABETES, vol. 57, 2008, pages 868 - 878
GUL RPARK JHKIM SYJANG KYCHEA JKKO JKKIM UH, CARDIOVASC RES, vol. 81, 2009, pages 582 - 591
KIM SYGUL RRAH SYKIM SHPARK SKIM MJKWON HJKIM UH, AM J PHYSIOL RENAL PHYSIOL., vol. 294, 2008, pages F989 - F989
PARTIDA-SANCHEZ SCOCKAYNE DAMONARD SJACOBSON ELOPPENHEIMER NGARVY BKUSSER KGOODRICH SHOWARD MHARMSEN A: "Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo", NAT MED, vol. 7, 2001, pages 1209 - 1216
MANIATIS ET AL.: "Molecular Cloning, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1994, JOHN, WILEY & SONS, INC.
"Remington's Pharmaceutical Sciences", 1995
GRAEFF RLEE HC: "A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity", BIOCHEM. J., vol. 361, 2002, pages 379 - 384
KANNT ASICKA KKROLL KKADEREIT DGOGELEIN HNAUNYN. SCHMIEDEBERGS: "Naunyn. Schmiedebergs", ARCH. PHARMACOL., vol. 385, 2012, pages 717 - 727
KIM SY, PARK KH, GUL R, JANG KY, KIM UH, PHYSIOL. RENAL PHYSIOL., vol. 296, 2009, pages F291 - F297
KIM SYPARK KHGUL RJANG KYKIM UH: "Role of kidney ADP-ribosyl cyclase in diabetic nephropathy", AM. J. PHYSIOL. RENAL PHYSIOL., vol. 296, 2009, pages F291 - F297, XP055770728, DOI: 10.1152/ajprenal.90381.2008
SHU BFENG YGUI YLU QWEI WXUE XSUN XHE WYANG JDAI C: "Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF- B signaling suppression", CELL. SIGNAL., vol. 42, 2018, pages 249 - 258, XP085303458, DOI: 10.1016/j.cellsig.2017.10.014
ALLAGNAT FHAEFLIGER JALAMBELET MLONGCHAMP ABERARD XMAZZOLAI LCORPATAUX JMDEGLISE S: "Nitric oxide deficit drives intimal hyperplasia in mouse models of hypertension", EUR. J. VASE. ENDOVASC. SURG., vol. 51, 2016, pages 733 - 742, XP029522368, DOI: 10.1016/j.ejvs.2016.01.024
LEE HC: "Structure and enzymatic functions of human CD38", MOL MED, vol. 12, 2006, pages 317 - 323
COWLEY AW JR: "Long-term control of arterial blood pressure", PHYSIOL. REV, vol. 72, 1992
GUL RPARK JHKIM SYJANG KYCHEA JKKO JKKIM UH: "Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy", CARDIOVASC. RES., vol. 81, 2009, pages 582 - 591, XP002599263, DOI: 10.1093/cvr/cvn232
KIM SYGUL RRAH SYKIM SHPARK SKIM MJKWON HJKIM UH: "Molecular mechanism of ADP-ribosyl cyclase activation in angiotensin II signaling in murine mesangial cells", AM. J. PHYSIOL. RENAL. PHYSIOL., vol. 294, 2008, pages F989 - F989
DATABASE Genkbank ANONYMOUS: "ATPase, Na+/K+ transporting, beta 1 polypeptide [Mus musculus]", XP055770749, retrieved from Proteins Database accession no. AAH27319.1
WOOHYUN KIM: "Development of Tissue-Specific Calcium Signal Blocker Technology", GOVERNMENT PROJECT FINAL REPORT, May 2012 (2012-05-01), pages 1 - 111, XP009525357
SEON-YOUNG KIM, PARK KWANG-HYUN, GUL RUKHSANA, JANG KYU YOON, KIM UH-HYUN: "Role of kidney ADP-ribosyl cyclase in diabetic nephropathy", AMERICAN JOURNAL OF PHYSIOLOGY: RENAL PHYSIOLOGY, 1 February 2009 (2009-02-01), pages F291 - F297, XP055770728, ISSN: 1931-857X, DOI: 10.1152/ajprenal.90381.2008
BERRIDGE MJBOOTMAN MDRODERICK HL: "Calcium signaling: dynamics, homeostasis and remodeling", NAT REV MOL CELL BIOL, vol. 4, 2003, pages 517 - 529
LEE HC, MOL. MED., vol. 12, 2006, pages 317 - 323
RESNICK LM: "Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of ''Syndrome X", AM. J. HYPERTENS., vol. 6, 1993, pages 123S - 134S
COWLEY AW, JR. PHYSIOL REV., vol. 72, 1992, pages 231 - 300
KIM BJPARK KHYIM CYTAKASAWA SOKAMOTO HIM MJKIM UH: "Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets", DIABETES, vol. 57, 2008, pages 868 - 878
GUL RPARK JHKIM SYJANG KYCHEA JKKO JKKIM UH, CARDIOVASC RES, vol. 81, 2009, pages 582 - 591
KIM SYGUL RRAH SYKIM SHPARK SKIM MJKWON HJKIM UH, AM J PHYSIOL RENAL PHYSIOL., vol. 294, 2008, pages F989 - F989
PARTIDA-SANCHEZ SCOCKAYNE DAMONARD SJACOBSON ELOPPENHEIMER NGARVY BKUSSER KGOODRICH SHOWARD MHARMSEN A: "Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo", NAT MED, vol. 7, 2001, pages 1209 - 1216
MANIATIS ET AL.: "Molecular Cloning, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1994, JOHN, WILEY & SONS, INC.
"Remington's Pharmaceutical Sciences", 1995
GRAEFF RLEE HC: "A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity", BIOCHEM. J., vol. 361, 2002, pages 379 - 384
KANNT ASICKA KKROLL KKADEREIT DGOGELEIN HNAUNYN. SCHMIEDEBERGS: "Naunyn. Schmiedebergs", ARCH. PHARMACOL., vol. 385, 2012, pages 717 - 727
KIM SY, PARK KH, GUL R, JANG KY, KIM UH, PHYSIOL. RENAL PHYSIOL., vol. 296, 2009, pages F291 - F297
KIM SYPARK KHGUL RJANG KYKIM UH: "Role of kidney ADP-ribosyl cyclase in diabetic nephropathy", AM. J. PHYSIOL. RENAL PHYSIOL., vol. 296, 2009, pages F291 - F297, XP055770728, DOI: 10.1152/ajprenal.90381.2008
SHU BFENG YGUI YLU QWEI WXUE XSUN XHE WYANG JDAI C: "Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF- B signaling suppression", CELL. SIGNAL., vol. 42, 2018, pages 249 - 258, XP085303458, DOI: 10.1016/j.cellsig.2017.10.014
ALLAGNAT FHAEFLIGER JALAMBELET MLONGCHAMP ABERARD XMAZZOLAI LCORPATAUX JMDEGLISE S: "Nitric oxide deficit drives intimal hyperplasia in mouse models of hypertension", EUR. J. VASE. ENDOVASC. SURG., vol. 51, 2016, pages 733 - 742, XP029522368, DOI: 10.1016/j.ejvs.2016.01.024
LEE HC: "Structure and enzymatic functions of human CD38", MOL MED, vol. 12, 2006, pages 317 - 323
COWLEY AW JR: "Long-term control of arterial blood pressure", PHYSIOL. REV, vol. 72, 1992
GUL RPARK JHKIM SYJANG KYCHEA JKKO JKKIM UH: "Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy", CARDIOVASC. RES., vol. 81, 2009, pages 582 - 591, XP002599263, DOI: 10.1093/cvr/cvn232
KIM SYGUL RRAH SYKIM SHPARK SKIM MJKWON HJKIM UH: "Molecular mechanism of ADP-ribosyl cyclase activation in angiotensin II signaling in murine mesangial cells", AM. J. PHYSIOL. RENAL. PHYSIOL., vol. 294, 2008, pages F989 - F989
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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