Title:
NOVEL ALKYNE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/153665
Kind Code:
A1
Abstract:
The present invention provides a compound that has an inhibitory effect on DYRK and that is represented by general formula (I) (in the formula, Q, R1, R2, and R3 are as defined in the description).
Inventors:
SAWA AYAKO (JP)
KAWAHATA WATARU (JP)
ASAMITSU YUKO (JP)
SAWA MASAAKI (JP)
IWATA YASUHIRO (JP)
MORIYAMA HIDEKI (JP)
TOJO SHINGO (JP)
URABE DAISUKE (JP)
KAWAHATA WATARU (JP)
ASAMITSU YUKO (JP)
SAWA MASAAKI (JP)
IWATA YASUHIRO (JP)
MORIYAMA HIDEKI (JP)
TOJO SHINGO (JP)
URABE DAISUKE (JP)
Application Number:
PCT/JP2021/003026
Publication Date:
August 05, 2021
Filing Date:
January 28, 2021
Export Citation:
Assignee:
CARNA BIOSCIENCES INC (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K45/00; A61K31/429; A61K31/437; A61P7/06; A61P19/08; A61P25/00; A61P25/16; A61P25/24; A61P25/28; A61P35/00; A61P43/00; C07D513/04; C07D513/14
Domestic Patent References:
| WO2010010797A1 | 2010-01-28 | |||
| WO2014069434A1 | 2014-05-08 |
Foreign References:
| JP2014525928A | 2014-10-02 | |||
| JP2019531318A | 2019-10-31 | |||
| JP2015107945A | 2015-06-11 |
Other References:
WANG DI; WANG FEI; TAN YEXIONG; DONG LIWEI; CHEN LEI; ZHU WEILIANG; WANG HONGYANG: "Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 1, 18 November 2011 (2011-11-18), AMSTERDAM, NL, pages 168 - 171, XP029121560, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2011.11.043
CZARNA ANNA, WANG JINHUA, ZELENCOVA DIANA, LIU YAO, DENG XIANMING, CHOI HWAN GEUN, ZHANG TINGHU, ZHOU WENJUN, CHANG JAE WON, KILDA: "Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 61, no. 17, 13 September 2018 (2018-09-13), pages 7560 - 7572, XP055843576, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01847
CZARNA ANNA, WANG JINHUA, ZELENCOVA DIANA, LIU YAO, DENG XIANMING, CHOI HWAN GEUN, ZHANG TINGHU, ZHOU WENJUN, CHANG JAE WON, KILDA: "Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 61, no. 17, 13 September 2018 (2018-09-13), pages 7560 - 7572, XP055843576, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01847
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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