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Title:
NOVEL ALPHA-GALACTOSYLCERAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR AN IMMUNE ADJUVANT, CONTAINING THE DERIVATIVES AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2011/052919
Kind Code:
A3
Abstract:
The present invention relates to alpga-galactosylceramide derivatives, to the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a pharmaceutical composition for an immune adjuvant, containing the derivatives as active ingredients. The compound of the present invention is remarkably stable at room temperature, and has superior solubility. The compound of the present invention is mediated by CD1d to activate NKT cells and thus induce cytokines, and therefore can be used as a therapeutic agent for diseases (autoimmune diseases, cancer, chronic allergic diseases, and all kinds of infectious diseases) which are known to be treated by alpha-galactosylceramides. Particularly, the compound of the present invention strongly induces the IL-4 cytokine, and thus can further be effectively used in the treatment of autoimmune diseases such as type 1 diabetes and multiple sclerosis, which can be controlled by the IL-4 cytokine.

Inventors:
KIM SANGHEE (KR)
KANG CHANG-YUIL (KR)
BAEK DONG JAE (KR)
LEE DOOHYUN (KR)
LEE YOON-SOOK (KR)
KANG MIN-HEE (KR)
LEE JAE-YOUNG (KR)
LEE KYOO-A (KR)
Application Number:
KR2010/007136
Publication Date:
November 03, 2011
Filing Date:
October 18, 2010
Export Citation:
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Assignee:
SNU R&DB FOUNDATION (KR)
KIM SANGHEE (KR)
KANG CHANG-YUIL (KR)
BAEK DONG JAE (KR)
LEE DOOHYUN (KR)
LEE YOON-SOOK (KR)
KANG MIN-HEE (KR)
LEE JAE-YOUNG (KR)
LEE KYOO-A (KR)
International Classes:
C07H15/00; A61K31/70; A61P35/00; A61P37/00
Foreign References:
KR20080062973A2008-07-03
KR20070023825A2007-02-28
Other References:
FRANCK, R. W. ET AL.: "a-C-Galactosylceramides: Synthesis and Immunology", ACCOUNTS OF CHEMICAL RESEARCH, vol. 39, October 2006 (2006-10-01), pages 692 - 701
Attorney, Agent or Firm:
LEE, Won-Hee (642-16 Yoksam-dongKangnam-ku, Seoul 135-080, KR)
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Claims: