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Title:
NOVEL ALPHA-GALACTOSYLCERAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR AN IMMUNE ADJUVANT, CONTAINING THE DERIVATIVES AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2011/052919
Kind Code:
A3
Abstract:
The present invention relates to alpga-galactosylceramide derivatives, to the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a pharmaceutical composition for an immune adjuvant, containing the derivatives as active ingredients. The compound of the present invention is remarkably stable at room temperature, and has superior solubility. The compound of the present invention is mediated by CD1d to activate NKT cells and thus induce cytokines, and therefore can be used as a therapeutic agent for diseases (autoimmune diseases, cancer, chronic allergic diseases, and all kinds of infectious diseases) which are known to be treated by alpha-galactosylceramides. Particularly, the compound of the present invention strongly induces the IL-4 cytokine, and thus can further be effectively used in the treatment of autoimmune diseases such as type 1 diabetes and multiple sclerosis, which can be controlled by the IL-4 cytokine.

Inventors:
KIM, Sanghee (#6-308 Hanyang Apt. Apgujung-dong Gangnam-gu, Seoul 135-794, 135-794, KR)
김상희 (서울시 강남구 압구정동 한양아파트 6-308, 135-794 Seoul, 135-794, KR)
KANG, Chang-Yuil (# Singu Blessvalley Apt. Bangbae-dong Seocho-gu, Seoul 137-060, 137-060, KR)
강창율 (서울시 서초구 방배동 신구블레스밸리아파트, 137-060 Seoul, 137-060, KR)
BAEK, Dong Jae (#203-302 Eunchun Apt. Inhun-dong Gwanak-gu, Seoul 151-780, 151-780, KR)
백동재 (서울시 관악구 인헌동 은천아파트 203-302, 151-780 Seoul, 151-780, KR)
LEE, Doohyun (312-5 Baekam-ri Yeomchi-eup Asan-si, Chungcheongnam-do 336-813, 336-813, KR)
이두현 (충청남도 아산시 염치읍 백암리 312-5, 336-813 Chungcheongnam-do, 336-813, KR)
Application Number:
KR2010/007136
Publication Date:
November 03, 2011
Filing Date:
October 18, 2010
Export Citation:
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Assignee:
SNU R&DB FOUNDATION (San 56-1 Sillim-dong Gwanak-gu, Seoul 151-742, 151-742, KR)
서울대학교 산학협력단 (서울시 관악구 신림동 산56-1, 151-742 Seoul, 151-742, KR)
KIM, Sanghee (#6-308 Hanyang Apt. Apgujung-dong Gangnam-gu, Seoul 135-794, 135-794, KR)
김상희 (서울시 강남구 압구정동 한양아파트 6-308, 135-794 Seoul, 135-794, KR)
KANG, Chang-Yuil (# Singu Blessvalley Apt. Bangbae-dong Seocho-gu, Seoul 137-060, 137-060, KR)
강창율 (서울시 서초구 방배동 신구블레스밸리아파트, 137-060 Seoul, 137-060, KR)
BAEK, Dong Jae (#203-302 Eunchun Apt. Inhun-dong Gwanak-gu, Seoul 151-780, 151-780, KR)
백동재 (서울시 관악구 인헌동 은천아파트 203-302, 151-780 Seoul, 151-780, KR)
LEE, Doohyun (312-5 Baekam-ri Yeomchi-eup Asan-si, Chungcheongnam-do 336-813, 336-813, KR)
International Classes:
C07H15/00; A61K31/70; A61P35/00; A61P37/00
Foreign References:
KR20080062973A2008-07-03
KR20070023825A2007-02-28
Other References:
FRANCK, R. W. ET AL.: 'a-C-Galactosylceramides: Synthesis and Immunology' ACCOUNTS OF CHEMICAL RESEARCH vol. 39, October 2006, pages 692 - 701
Attorney, Agent or Firm:
LEE, Won-Hee (8th Fl. Sung-ji Heights II, 642-16 Yoksam-dongKangnam-ku, Seoul 135-080, 135-080, KR)
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Claims: