Title:
NOVEL AMIDE DERIVATIVE AND SKIN WHITENING AGENT
Document Type and Number:
WIPO Patent Application WO2010110353
Kind Code:
A1
Abstract:
Disclosed is a novel compound which has melanin production inhibitory activity, or the like. Specifically disclosed is a compound represented by general formula (I) (wherein the symbols are as defined in the description) or a salt thereof. Also specifically disclosed is a skin whitening agent which contains the compound or a salt thereof.
Inventors:
AMINO YUSUKE (JP)
TAKINO YOSHINOBU (JP)
OHASHI SATORU (JP)
OKURA FUMIE (JP)
KANEKO MEGUMI (JP)
TAKINO YOSHINOBU (JP)
OHASHI SATORU (JP)
OKURA FUMIE (JP)
KANEKO MEGUMI (JP)
Application Number:
PCT/JP2010/055162
Publication Date:
September 30, 2010
Filing Date:
March 25, 2010
Export Citation:
Assignee:
AJINOMOTO KK (JP)
AMINO YUSUKE (JP)
TAKINO YOSHINOBU (JP)
OHASHI SATORU (JP)
OKURA FUMIE (JP)
KANEKO MEGUMI (JP)
AMINO YUSUKE (JP)
TAKINO YOSHINOBU (JP)
OHASHI SATORU (JP)
OKURA FUMIE (JP)
KANEKO MEGUMI (JP)
International Classes:
C07C235/34; A61K8/42; A61K8/49; A61K31/165; A61K31/4045; A61K31/405; A61P43/00; A61Q19/02; C07D209/14; C07D209/20; C07D405/12
Foreign References:
| JPH0853332A | 1996-02-27 | |||
| JPH08175959A | 1996-07-09 | |||
| JP2006052152A | 2006-02-23 | |||
| JP2007131622A | 2007-05-31 |
Other References:
SABRINA 0. ET AL.: "Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase", BIOORG. MED. CHEM. LETT., vol. 16, 2006, pages 2252 - 2255
SUNG J. C. ET AL.: "N-Benzylbenzamides: A new class of potent tyrosinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 2682 - 2684, XP028674533, DOI: doi:10.1016/j.bmcl.2006.02.018
See also references of EP 2412701A4
FUNAYAMA, M., ARAKAWA, H., YAMAMOTO, R., NISHINO, T., SHIN, T., MURAO, S.: "Effect of a- and p-arubutin on activity of tyrosinases from mushroom, and mouse melanoma", BIOSCI. BIOTECH. BIOCHEM., vol. 59, 1995, pages 143 - 144
KOUJI MIYAZAKI, YUMIKO NISHIDA, MINORU ITIOKA: "Inhibitory Effects of Melanogenic Inhibitors on Dendricity of Cultured B16 Mouse Melanoma Cells", JOURNAL OF JAPANESE COSMETIC SCIENCE SOCIETY, vol. 22, no. 3, 1998, pages 182 - 186
KIYOHARU SUGIYAMA: "Evaluation of novel whitening agent - Rucinol (Shinki bihakuzai no hyouka - Rucinol ni tsuite", THE JOURNAL OF JAPAN HAIR SCIENCE ASSOCIATION, vol. 30, no. 3, 1998, pages 2 - 6
DONG-SEOK KIM, SO-YOUNG KIM, SEO-HYOUNG PARK, YEONG-GON CHOI, SUN-BANG KWON, MYO-KYOUNG KIM, JUNG-IM NA, SANG-WOONG YOUN, KYOUNG-C: "Inhibitory Effects of 4-n-Butylresorcinol on Tyrosinase Activity and Melanin Synthesis", BIOL. PHARM. BULL., vol. 28, no. 12, 2005, pages 2216 - 2219, XP002462454, DOI: doi:10.1248/bpb.28.2216
SUNG J. C. ET AL.: "N-Benzylbenzamides: A new class of potent tyrosinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 2682 - 2684, XP028674533, DOI: doi:10.1016/j.bmcl.2006.02.018
See also references of EP 2412701A4
FUNAYAMA, M., ARAKAWA, H., YAMAMOTO, R., NISHINO, T., SHIN, T., MURAO, S.: "Effect of a- and p-arubutin on activity of tyrosinases from mushroom, and mouse melanoma", BIOSCI. BIOTECH. BIOCHEM., vol. 59, 1995, pages 143 - 144
KOUJI MIYAZAKI, YUMIKO NISHIDA, MINORU ITIOKA: "Inhibitory Effects of Melanogenic Inhibitors on Dendricity of Cultured B16 Mouse Melanoma Cells", JOURNAL OF JAPANESE COSMETIC SCIENCE SOCIETY, vol. 22, no. 3, 1998, pages 182 - 186
KIYOHARU SUGIYAMA: "Evaluation of novel whitening agent - Rucinol (Shinki bihakuzai no hyouka - Rucinol ni tsuite", THE JOURNAL OF JAPAN HAIR SCIENCE ASSOCIATION, vol. 30, no. 3, 1998, pages 2 - 6
DONG-SEOK KIM, SO-YOUNG KIM, SEO-HYOUNG PARK, YEONG-GON CHOI, SUN-BANG KWON, MYO-KYOUNG KIM, JUNG-IM NA, SANG-WOONG YOUN, KYOUNG-C: "Inhibitory Effects of 4-n-Butylresorcinol on Tyrosinase Activity and Melanin Synthesis", BIOL. PHARM. BULL., vol. 28, no. 12, 2005, pages 2216 - 2219, XP002462454, DOI: doi:10.1248/bpb.28.2216
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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