NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF

Title:

NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF

Document Type and Number:

WIPO Patent Application WO/1998/032742

Kind Code:

A1

Abstract:

Amide derivatives represented by general formula (I), or their salts and medicinal compositions containing these derivatives and pharmaceutically acceptable carriers, wherein each symbol has the following meaning: A: heteroarylene; X: a bond, O, S, -NR?5�-, -NR?5�CO-, -NR?5�CONH-, -NR?5�SO�2?- or -NR?5�C(=NH)NH-; R?1�: H, optionally substituted lower aryl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted cycloalkyl; R?2a� and R?2b�: being the same or different from each other and each representing H or lower alkyl; R?3�: H or lower alkyl; R?4a� and R?4b�: being the same or different from each other and each representing H or OH, or R?4a� and R?4b� forming together =O or =N~O-lower alkyl; and R?5�: H or lower alkyl. These compounds are useful as remedies for diabetes having an insulin secretion accelerating effect together with an insulin sensitivity increasing effect.

Inventors:

MARUYAMA TATSUYA (JP)
ONDA KENICHI (JP)
HAYAKAWA MASAHIKO (JP)
TAKAHASHI TAKUMI (JP)
SUZUKI TAKAYUKI (JP)
MATSUI TETSUO (JP)

Application Number:

PCT/JP1998/000237

Publication Date:

July 30, 1998

Filing Date:

January 22, 1998

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)
MARUYAMA TATSUYA (JP)
ONDA KENICHI (JP)
HAYAKAWA MASAHIKO (JP)
TAKAHASHI TAKUMI (JP)
SUZUKI TAKAYUKI (JP)
MATSUI TETSUO (JP)

International Classes:

A61K31/41; A61K31/415; A61K31/425; A61P3/10; A61P5/50; C07C217/16; C07C271/16; C07C271/20; C07D233/54; C07D233/61; C07D233/64; C07D235/16; C07D249/08; C07D249/12; C07D257/04; C07D277/30; C07D277/38; C07D277/40; C07D277/42; C07D277/46; C07D285/12; C07D471/04; (IPC1-7): C07D233/64; C07D249/12; C07D257/04; C07D277/40; C07D277/30; A61K31/415; A61K31/41; A61K31/425

Foreign References:

JPH08239349A	1996-09-17
JPH03193747A	1991-08-23

Other References: