Title:
NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF UGS
Document Type and Number:
WIPO Patent Application WO/2002/022556
Kind Code:
A1
Abstract:
Amide derivatives represented by the following general formula (1) which have a C5$g(a) receptor antagonism, wherein each symbol has the meaning as defined in the description. These amide derivatives, optically active isomers thereof or pharmaceutically acceptable salts of the same are useful as preventives and remedies for diseases or syndromes caused by inflammation induced by C5$g(a) [for example, immunological diseases such as rheumatism and systemic lupus erythematosus, allergic diseases such as sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease and asthma, atherosclerosis, heart infarction, brain infarction, psoriasis, Alzheimer's disease and important organistic breakdown (for example, pneumonia, nephritis, hepatitis, pancreatitis) induced by leukocyte activation caused by ischemic reperfusion, burn or surgical invasion]. Moreover, they are useful as preventives and remedies for infection with bacteria and viruses mediated by C5$g(a) receptor.
Inventors:
NAKAMURA MITSUHARU (JP)
KAMAHORI TAKAO (JP)
ISHIBUCHI SEIGO (JP)
NAKA YOICHI (JP)
SUMICHIKA HIROSHI (JP)
ITOH KATSUHIKO (JP)
KAMAHORI TAKAO (JP)
ISHIBUCHI SEIGO (JP)
NAKA YOICHI (JP)
SUMICHIKA HIROSHI (JP)
ITOH KATSUHIKO (JP)
Application Number:
PCT/JP2001/007977
Publication Date:
March 21, 2002
Filing Date:
September 14, 2001
Export Citation:
Assignee:
MITSUBISHI PHARMA CORP (JP)
NAKAMURA MITSUHARU (JP)
KAMAHORI TAKAO (JP)
ISHIBUCHI SEIGO (JP)
NAKA YOICHI (JP)
SUMICHIKA HIROSHI (JP)
ITOH KATSUHIKO (JP)
NAKAMURA MITSUHARU (JP)
KAMAHORI TAKAO (JP)
ISHIBUCHI SEIGO (JP)
NAKA YOICHI (JP)
SUMICHIKA HIROSHI (JP)
ITOH KATSUHIKO (JP)
International Classes:
C07C233/59; C07C233/60; C07C233/62; C07C235/40; C07C255/29; C07C255/60; C07C317/32; C07C317/40; C07C323/40; C07C327/46; C07D213/40; C07D213/64; C07D213/65; C07D213/69; C07D213/74; C07D213/75; C07D215/50; C07D231/12; C07D233/61; C07D277/28; C07D295/13; C07D295/135; C07D295/185; C07D309/12; C07D311/04; C07D311/66; C07D317/58; C07D317/66; C07D319/18; C07D333/20; C07D333/36; C07D335/06; C07D401/06; C07D401/12; C07D401/14; C07D405/12; C07D409/06; C07D409/14; C07D417/12; C07D417/14; C07D513/04; C07D521/00; (IPC1-7): C07C233/59; C07C233/60; C07C233/62; C07C235/82; C07C255/29; C07C255/60; C07C317/32; C07C321/28; C07D295/182; C07D309/12; C07D335/06; C07D215/227; C07D317/58; C07D231/12; C07D213/40; C07D213/74; C07D213/65; C07D213/64; C07D513/04; C07D333/20; C07D213/69; C07D295/135; C07D233/61; C07D401/12; C07D317/66; C07D277/28; C07D401/06; C07D417/14; C07D401/14; C07D417/12; C07D405/12; C07D409/14; A61K31/67; A61K31/275; A61K31/5375; A61K31/351; A61K31/353; A61K31/382; A61K31/4704; A61K31/36; A61K31/415; A61K31/44; A61K31/429; A61K31/381; A61K31/444; A61K31/40; A61K31/4164; A61K31/4453; A61K31/4439; A61K31/426; A61K31/4155; A61K31/4545; A61K31/5377; A61P43/00; A61P37/06; A61P31/04; A61P11/00; A61P37/08; A61P9/10; A61P17/06; A61P25/28; A61P31/12; A61K45/06; C07D319/18; A61K31/357; C07D311/58; C07D311/64; C07D495/04
Domestic Patent References:
| WO1994027971A1 | 1994-12-08 |
Foreign References:
| EP0978279A1 | 2000-02-09 | |||
| US5491152A | 1996-02-13 | |||
| JPH05294960A | 1993-11-09 | |||
| EP0181136A2 | 1986-05-14 |
Other References:
See also references of EP 1318140A4
Attorney, Agent or Firm:
Takashima, Hajime (Fushimimachi 4-chome Chuo-ku Osaka-shi, Osaka, JP)
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