Title:
NOVEL AMIDINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1986/000893
Kind Code:
A1
Abstract:
Novel amidine compounds represented by formula (I) (wherein R1 and R2 each represents hydrogen, a straight or branched chain alkyl group containing 1 to 6 carbon atoms, R3 represents a straight or branched chain alkyl group containing 1 to 6 carbon atoms or R4-B-(VH2)n-, n represents -O- or NH-, R4 represents hydrogen, R5-CO- or $(1,7)$-CH2-, R5 represents a straight or branched chain alkyl group containing 1 to 15 carbon atoms, and R1 and R3 may optionally form a ring via 2 to 4 carbon atoms which may contain a double bond or a straight or branched alkyl substituent containing 1 to 4 carbon atoms) and medicinally acceptable acid addition salts thereof are useful as orally administrable anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin, and anti-complement agents.
Inventors:
FUJII SETSUROU (JP)
OKUTOME TOSHIYUKI (JP)
NAKAYAMA TOYOO (JP)
NUNOMURA SHIGEKI (JP)
SUDO KIMIO (JP)
WATANABE SHINICHI (JP)
KURUMI MASATERU (JP)
AOYAMA TAKUO (JP)
OKUTOME TOSHIYUKI (JP)
NAKAYAMA TOYOO (JP)
NUNOMURA SHIGEKI (JP)
SUDO KIMIO (JP)
WATANABE SHINICHI (JP)
KURUMI MASATERU (JP)
AOYAMA TAKUO (JP)
Application Number:
PCT/JP1985/000392
Publication Date:
February 13, 1986
Filing Date:
July 12, 1985
Export Citation:
Assignee:
TORII & CO LTD (JP)
International Classes:
A61K31/24; A61K31/245; A61K31/41; A61K31/415; A61K31/4184; A61K31/495; A61K31/496; A61P1/00; A61P1/18; A61P7/00; A61P7/02; A61P7/04; A61P43/00; C07C277/08; C07C279/18; C07D233/50; C07D233/88; C07D235/30; C07D239/14; C12N9/99; (IPC1-7): C07C129/12; C07D231/06; A61K31/245
Foreign References:
| JPS57179146A | 1982-11-04 |
Other References:
See also references of EP 0190356A1
Download PDF: