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Title:
NOVEL AMIDRAZONE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/1998/058905
Kind Code:
A1
Abstract:
Amidrazone derivatives of formula (I) useful for prevention or treatment of lupus mycosis attributable to fungi, such as Candida, Aspergillus, and Cryptococcus, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R?a¿ represents: (1) an optionally substituted monocyclic to tricyclic aromatic hydrocarbon, (2) an optionally substituted monocyclic to tricyclic saturated or unsaturated hetero ring containing one or more hetero atoms selected from N, O and S, (3) an optionally substituted and optionally cross-linked cycloalkyl, or (4) an optionally substituted and optionally cross-linked cycloalkenyl; R?b¿ represents (1) an optionally substituted monocyclic to tricyclic aromatic hydrocarbon or (2) an optionally substituted monocyclic to tricyclic saturated or unsaturated hetero ring containing one or more hetero atoms selected from N, O and S; <o>...</o> represents a single bond or a double bond; n is 1 to 8; A represents a bond or a lower alkylene optionally substituted by a lower alkyl; and X represents a bond, -CO-, -CO¿2?-, -CONR?g¿-, -COCONR?g1¿, -CH=CHCONR?g2¿-, -NR?g3¿, -NR?g4¿CO-, -NR?g5¿CO¿2?-, -NR?g6¿CONR?g7¿-, -O-, -OCO-, -OCONR?g8¿-, -OCH¿2?CONR?g9¿-, -S-, -SO-, -SO¿2?-, -SO¿2?NR?g10¿-, or -SO¿2?NR?g11¿CO-.

Inventors:
Kageyama, Shunji (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Kontani, Toru (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Fujii, Masahiro (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Igarashi, Kiyoshi (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Yamamoto, Osamu (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Application Number:
PCT/JP1998/002817
Publication Date:
December 30, 1998
Filing Date:
June 24, 1998
Export Citation:
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Assignee:
YAMANOUCHI PHARMACEUTICAL CO., LTD. (3-11, Nihonbashi-Honcho 2-chome Chuo-ku, Tokyo, 103-8411, JP)
Kageyama, Shunji (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Kontani, Toru (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Fujii, Masahiro (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Igarashi, Kiyoshi (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
Yamamoto, Osamu (Yamanouchi Pharmaceutical Co. Ltd, 21, Miyukigaok, Tsukuba-shi Ibaraki, 305-8585, JP)
International Classes:
C07C257/22; C07D207/416; C07D209/12; C07D209/88; C07D213/32; C07D213/64; C07D213/65; C07D213/77; C07D213/78; C07D213/82; C07D215/12; C07D215/14; C07D215/26; C07D215/46; C07D231/12; C07D237/14; C07D237/16; C07D237/22; C07D241/20; C07D241/24; C07D249/08; C07D263/58; C07D265/36; C07D277/38; C07D277/40; C07D277/42; C07D277/46; C07D279/16; C07D307/68; C07D311/14; C07D319/20; C07D333/38; C07D333/70; C07D401/12; C07D413/12; C07D473/08; C07D473/10; C07D487/04; C07D521/00; C07D207/40; (IPC1-7): C07C257/22; A61K31/155; A61K31/165; A61K31/17; A61K31/18; A61K31/215; A61K31/27; A61K31/275; A61K31/35; A61K31/38; A61K31/415; A61K31/425; A61K31/445; A61K31/47; A61K31/495; C07D211/40; C07D215/18; C07D215/26; C07D215/32; C07D231/12; C07D231/14; C07D249/08; C07D277/38; C07D277/44; C07D295/14; C07D295/18; C07D311/22; C07D333/38; C07D487/04
Attorney, Agent or Firm:
Nagai, Shozo (Yamanouchi Pharmaceutical Co. Ltd, Patent & Information Dept., 17-1, Hasune 3-chom, Itabashi-ku Tokyo, 174-8612, JP)
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