NOVEL AMINO ALCOHOL DERIVATIVE OR SALT THEREOF

Title:

NOVEL AMINO ALCOHOL DERIVATIVE OR SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/1993/012069

Kind Code:

A1

Abstract:

A compound represented by general formula (I), a pharmaceutical composition containing the same, and a process for producing the same, wherein R?1¿: hydrogen, lower alkyl, lower alkanoyl or aralkyl; R?2¿: optionally hydroxylated lower alkyl or (a); ring B: benzene ring or five- or six-membered heterocycle bearing 1 to 3 heteroatoms selected among N, O and S; R?3¿: hydrogen, lower alkyl, lower alkenyl, lower alkanoyl, lower alkoxycarbonyl or aryl; R?4¿: lower alkyl; R?5¿, R?6¿ and R?7¿ may be the same or different from each other and each represents hydrogen, halogen, alkyl, lower alkoxy, aryloxy or cyano, provided that two adjacent groups among R?5¿, R?6¿ and R?7¿ may be combined together to represent -(CH¿2?)¿4?-, -(CH¿2?)¿3?-, -CH=CH-CH-CH- or (b); and n: an integer of 0 to 3. This compound (I) has a squalene epoxidase inhibiting activity and is useful for preventing and treating various diseases caused by cholesterol, such as arteriosclerosis.

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Inventors:

MATSUDA KOYO (JP)
HARADA HIRONORI (JP)
TSUZUKI RYUJI (JP)
MORIHIRA KOICHIRO (JP)
ITO NORIKI (JP)
KAKUTA HIROTOSHI (JP)
IIZUMI YUICHI (JP)

Application Number:

PCT/JP1992/001629

Publication Date:

June 24, 1993

Filing Date:

December 15, 1992

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)

International Classes:

A61K31/195; A61K31/38; C07C217/58; C07C217/84; C07C229/40; C07C255/58; C07D207/34; C07D207/50; C07D213/38; C07D231/38; C07D241/12; C07D241/20; C07D249/14; C07D261/14; C07D275/03; C07D277/32; C07D277/42; C07D285/135; C07D303/22; C07D333/36; C07D417/04; C07D275/02; C07D285/12; (IPC1-7): A61K31/135; A61K31/38; C07C217/58; C07C217/82; C07C225/22; C07C255/58; C07D207/50; C07D213/36; C07D231/10; C07D241/10; C07D249/14; C07D261/06; C07D275/03; C07D277/32; C07D285/12; C07D333/36; C07D417/04

Foreign References:

JPS4842869B1	1973-12-14
JPS5537544B1	1980-09-29

Other References:

CHEMICAL ABSTRACTS, Vol. 85, No. 13, SMITH L.H., "Beta-Adrenergic Blocking Agents. 13. (3-Amino-2-Hydroxypropoxy) Benzamides", Abstract No. 87094k; & J. MED. CHEM., 19 (9), (1976), 1119-23.

Attorney, Agent or Firm:

Nagai, Shozo (Patent Department, 1-8, Azusawa 1-chom, Itabashi-ku Tokyo 174, JP)

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