Title:
NOVEL AMPHIPATHIC MOLECULE BASED ON TANDEM MALONATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/190452
Kind Code:
A1
Abstract:
The present invention relates to a novel amphipathic molecule based on tandem malonate, a method for producing same, and a method for extracting, solubilizing, stabilizing, crystallizing, or analyzing a membrane protein by using the amphipathic molecule. The compound, compared to existing compounds, can more efficiently extract, from a cell membrane, membrane proteins having various structures and characteristics, can stably store same in an aqueous solution for a long period of time, and can be utilized for functional and structural analyses thereof. Functional and structural analyses of membrane proteins are closely related to drug development and thus are one of the fields receiving the most attention in biology and chemistry today.
Inventors:
CHAE PIL SEOK (KR)
HUSSAIN HAZRAT (KR)
HUSSAIN HAZRAT (KR)
Application Number:
PCT/KR2017/004258
Publication Date:
October 18, 2018
Filing Date:
April 21, 2017
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C07H15/26; C07H15/14; G01N33/68
Foreign References:
| US20130001465A1 | 2013-01-03 |
Other References:
EHSAN, M. ET AL.: "Highly branched pentasaccharide-bearing amphiphiles for membrane protein studies", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 11, 2016, pages 3789 - 3796, XP055462432
ILKER, M. F.: "Modular norbornene derivatives for the preparation of well-defined amphiphilic polymers: Study of the lipid membrane disruption activities", MACROMOLECULES, vol. 37, no. 3, 2004, pages 694 - 700, XP055536713
CHAE, P. S.: "Tripod amphiphiles for membrane protein manipulation", MOLECULAR BIOSYSTEMS, vol. 6, 2010, pages 89 - 94, XP055536722
CHAE, P. S.: "Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study", CHEMICAL COMMUNICATIONS, vol. 49, no. 23, 2013, pages 2287 - 2289, XP055536723
ILKER, M. F.: "Modular norbornene derivatives for the preparation of well-defined amphiphilic polymers: Study of the lipid membrane disruption activities", MACROMOLECULES, vol. 37, no. 3, 2004, pages 694 - 700, XP055536713
CHAE, P. S.: "Tripod amphiphiles for membrane protein manipulation", MOLECULAR BIOSYSTEMS, vol. 6, 2010, pages 89 - 94, XP055536722
CHAE, P. S.: "Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study", CHEMICAL COMMUNICATIONS, vol. 49, no. 23, 2013, pages 2287 - 2289, XP055536723
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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