Title:
NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/098308
Kind Code:
A1
Abstract:
An anthranilic acid derivative represented by the general formula below or a salt thereof: wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted or the like; R4 represents a phenyl, cycloalkyl or pyridyl group which may be substituted or the like; and X1 represents an alkylene or alkenylene group which may be substituted or a bond; X2 represents the general formula: -X3-X4- or -X4-X3- where X3 represents a sulfur atom, an imino group, a bond or the like, X4 represents an alkylene or alkenylene group which may be substituted or a bond, or the like. The derivative or salt thereof has an effect of inhibiting the production of MMP-13, and therefore is useful as a therapeutic agent for rheumatoid arthritis, osteoarthritis, cancer or the like.
Inventors:
YOKOTANI JUNICHI (JP)
TANIGUCHI YOICHI (JP)
HARA EIJI (JP)
AKITSU HITOSHI (JP)
TANAKA HIDEHIKO (JP)
ANZAI SHUZO (JP)
TANIGUCHI YOICHI (JP)
HARA EIJI (JP)
AKITSU HITOSHI (JP)
TANAKA HIDEHIKO (JP)
ANZAI SHUZO (JP)
Application Number:
PCT/JP2006/304981
Publication Date:
September 21, 2006
Filing Date:
March 14, 2006
Export Citation:
Assignee:
TOYAMA CHEMICAL CO LTD (JP)
YOKOTANI JUNICHI (JP)
TANIGUCHI YOICHI (JP)
HARA EIJI (JP)
AKITSU HITOSHI (JP)
TANAKA HIDEHIKO (JP)
ANZAI SHUZO (JP)
YOKOTANI JUNICHI (JP)
TANIGUCHI YOICHI (JP)
HARA EIJI (JP)
AKITSU HITOSHI (JP)
TANAKA HIDEHIKO (JP)
ANZAI SHUZO (JP)
International Classes:
C07C229/58; A61K31/196; A61K31/245; A61K31/343; A61K31/351; A61K31/36; A61K31/381; A61K31/402; A61K31/404; A61K31/415; A61K31/416; A61K31/4184; A61K31/42; A61K31/426; A61K31/428; A61K31/433; A61K31/4406; A61K31/4418; A61K31/47; A61K31/472; A61K31/5375; A61P19/02; A61P43/00; C07C229/60; C07C229/64; C07C229/66; C07C233/54; C07C233/55; C07C255/58; C07C311/08; C07C311/21; C07C317/48; C07C323/63; C07D209/08; C07D213/55; C07D213/64; C07D215/38; C07D217/18; C07D217/22; C07D231/56; C07D235/08; C07D241/40; C07D277/62; C07D285/12; C07D295/12; C07D307/79; C07D307/81; C07D309/12; C07D317/60; C07D317/66; C07D317/68; C07D319/18; C07D321/12; C07D333/24; C07D333/68; C07D405/12; C07D409/12
Domestic Patent References:
| WO2005019188A1 | 2005-03-03 | |||
| WO2002064080A2 | 2002-08-22 |
Foreign References:
| JPH11199565A | 1999-07-27 | |||
| JPS63216820A | 1988-09-09 | |||
| JPS53101536A | 1978-09-05 | |||
| JPS49117442A | 1974-11-09 | |||
| JPS5466645A | 1979-05-29 | |||
| JPS5034028A | 1975-04-02 | |||
| GB2406856A | 2005-04-13 | |||
| JP2005502632A | 2005-01-27 | |||
| JP2004518726A | 2004-06-24 | |||
| JP2004523546A | 2004-08-05 |
Other References:
CURRENT ONCOLOGY REPORTS, vol. 6, 2004, pages 96 - 102
ANNALS OF THE RHEUMATIC, vol. 60, 2001, pages 62 - 67
BIOCHEMICAL SOCIETY SYMPOSIA, vol. 70, 2003, pages 115 - 123
LEVIN ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 235 - 238
AVENTIS RES. & TECH., vol. 15, no. 2, pages 237 - 241
ANNALS OF THE RHEUMATIC, vol. 60, 2001, pages 62 - 67
BIOCHEMICAL SOCIETY SYMPOSIA, vol. 70, 2003, pages 115 - 123
LEVIN ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 235 - 238
AVENTIS RES. & TECH., vol. 15, no. 2, pages 237 - 241
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