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Title:
NOVEL ANTI-DC-SIGN ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2005058244
Kind Code:
A3
Abstract:
Antibodies to DC-SIGN are disclosed which are capable of modulating the interaction of dendritic cells and T cells. In some embodiments, the antibodies inhibit the interaction of dendritic cells and T cells. In other embodiments, the antibodies are combined with peptides which are internalized in dendritic cells and presented to T cells, thereby generating an immune response to the peptide. The antibodies of the present disclosure may, in some embodiments, be useful in blocking viral binding, infection, and transmission.

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Inventors:
BOWDISH KATHERINE S (US)
KRETZ-ROMMEL ANKE (US)
Application Number:
PCT/US2004/041788
Publication Date:
December 29, 2005
Filing Date:
December 15, 2004
Export Citation:
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Assignee:
ALEXION PHARMA INC (US)
BOWDISH KATHERINE S (US)
KRETZ-ROMMEL ANKE (US)
International Classes:
A61K45/00; A61K47/00; A61K47/48; C07K16/00; C07K16/28; C12P21/08; G01N33/53; G01N33/564; G01N33/574; A61K; (IPC1-7): A61K45/00; A61K47/00; C07K16/00; C12P21/08; G01N33/53
Foreign References:
US5530101A1996-06-25
Other References:
BARIBAUD F. ET AL: "Functional and Antigenic Characterization of Human, Rhesus Macaque, Pigtailed Macaque, and Murine DC-SIGN.", J VIROL., vol. 75, no. 21, November 2001 (2001-11-01), pages 10281 - 10289, XP002327292
WU L. ET AL: "Functional Evaluation of DC-SIGN Monoclonal Antibodies Reveals DC-SIGN Interactions with ICAM-3 Do Not Promote Human Immunodeficiency Virus Type I Transmission.", J VIROL., vol. 76, no. 12, June 2002 (2002-06-01), pages 5905 - 5914, XP002976661
GRUBER A. ET AL: "Functional aspects of binding of monoclonal antibody DCN46 to DC-SIGN on dendritic cells.", IMMUNOL LETTS., vol. 84, 2002, pages 103 - 108, XP002992337
See also references of EP 1699487A4
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