Title:
NOVEL ANTI-GLYPICAN 3 ANTIBODY AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2017/074074
Kind Code:
A1
Abstract:
The present invention relates to an antibody specifically binding to glypican 3 (GPC3), a nucleic acid encoding the antibody, a vector and a host cell containing the nucleic acid, a method of preparing the antibody, and a pharmaceutical composition for treating cancer or tumor, containing the antibody as an active ingredient. The antibody specifically binding to glypican 3 according to the present invention may be effectively used to treat cancer or tumor, particularly, hepatocellular carcinoma due to high affinity and specificity to glypican 3.
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Inventors:
PARK JAE CHAN (KR)
KIM KISU (KR)
LEE MIJUNG (KR)
LEE EUN-HEE (KR)
KIM DONG-SIK (KR)
SONG EUN JUNG (KR)
KIM SUJEONG (KR)
LIM HYUNG-KWON (KR)
LEE KYUHYUN (KR)
WON JONGWHA (KR)
CHOI SOONGYU (KR)
PARK YOUNG SEOUB (KR)
KIM KISU (KR)
LEE MIJUNG (KR)
LEE EUN-HEE (KR)
KIM DONG-SIK (KR)
SONG EUN JUNG (KR)
KIM SUJEONG (KR)
LIM HYUNG-KWON (KR)
LEE KYUHYUN (KR)
WON JONGWHA (KR)
CHOI SOONGYU (KR)
PARK YOUNG SEOUB (KR)
Application Number:
PCT/KR2016/012193
Publication Date:
May 04, 2017
Filing Date:
October 27, 2016
Export Citation:
Assignee:
MOGAM INST FOR BIOMEDICAL RES (KR)
International Classes:
C07K16/30; A61K39/395
Foreign References:
| US8680247B2 | 2014-03-25 | |||
| US20150147330A1 | 2015-05-28 | |||
| KR20130014698A | 2013-02-08 | |||
| US20080124330A1 | 2008-05-29 |
Other References:
HANAOKA ET AL.: "Glypican-3 targeted human heavy chain antibody as a drug carrier for hepatocellular carcinoma therapy", MOLECULAR PHARMACEUTICS, vol. 12, 8 May 2015 (2015-05-08), pages 2151 - 2157, XP055207644
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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