Title:
NOVEL ANTI-HUMAN MUC1 ANTIBODY Fab FRAGMENT
Document Type and Number:
WIPO Patent Application WO/2018/092885
Kind Code:
A1
Abstract:
[Problem] To provide an anti-human MUC1 antibody Fab fragment, which is expected to be useful for the diagnosis and/or treatment of cancer, particularly the diagnosis and/or treatment of breast cancer or bladder cancer, and a diagnosis means and/or a therapeutic means using a complex containing the Fab fragment. [Solution] An anti-human MUC1 antibody Fab fragment which contains a heavy chain fragment containing a heavy-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 8 or 10, and a light chain containing a light-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 12; and a complex containing the Fab fragment.
Inventors:
MORINAKA AKIFUMI (JP)
SHIRAI HIROKI (JP)
HIRAYAMA KAZUNORI (JP)
HOSOGAI NAOMI (JP)
DOIHARA HITOSHI (JP)
SHIRAI HIROKI (JP)
HIRAYAMA KAZUNORI (JP)
HOSOGAI NAOMI (JP)
DOIHARA HITOSHI (JP)
Application Number:
PCT/JP2017/041486
Publication Date:
May 24, 2018
Filing Date:
November 17, 2017
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C12N15/09; A61K39/395; A61K49/16; A61P35/00; C07K16/18; C07K16/30; C07K17/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| WO2010050528A1 | 2010-05-06 | |||
| WO2011135869A1 | 2011-11-03 | |||
| WO2016130726A1 | 2016-08-18 | |||
| WO2010050528A1 | 2010-05-06 | |||
| WO2008040362A2 | 2008-04-10 | |||
| WO1990007861A1 | 1990-07-26 |
Foreign References:
| JP2010505775A | 2010-02-25 | |||
| JP2013505702A | 2013-02-21 | |||
| JP2013517487A | 2013-05-16 |
Other References:
NAT. REV. CANCER, vol. 4, no. 1, January 2004 (2004-01-01), pages 45 - 60
MOD. PATHOL., vol. 18, no. 10, October 2005 (2005-10-01), pages 1295 - 304
HUM. PATHOL., vol. 39, no. 1, January 2008 (2008-01-01), pages 126 - 36
INT. J. ONCOL., vol. 16, no. 1, January 2000 (2000-01-01), pages 55 - 64
PLOS ONE, vol. 9, no. 3, March 2014 (2014-03-01), pages e92742
HISTOPATHOLOGY, vol. 37, no. 3, September 2000 (2000-09-01), pages 218 - 23
J. PATHOL., vol. 200, no. 3, July 2003 (2003-07-01), pages 357 - 69
J. PATHOL., vol. 190, no. 4, March 2000 (2000-03-01), pages 437 - 43
INT. J. ONCOL., vol. 24, no. 1, January 2004 (2004-01-01), pages 107 - 13
MOD. PATHOL., vol. 17, no. 2, February 2004 (2004-02-01), pages 180 - 8
GYNECOL. ONCOL., vol. 105, no. 3, June 2007 (2007-06-01), pages 695 - 702
AM. J. CLIN. PATHOL., vol. 122, no. 1, July 2004 (2004-07-01), pages 61 - 9
PATHOL. RES. PRACT., vol. 206, no. 8, 15 August 2010 (2010-08-15), pages 585 - 9
TAKASHI TSURUO: "Molecular Target Therapy of Cancer", 15 September 2008, NANZANDO CO., LTD., pages: 332 - 336
J. NUCL. MED., vol. 57, no. 7, July 2016 (2016-07-01), pages 1105 - 1111
NUCL. MED. BIOL., vol. 37, no. 8, November 2010 (2010-11-01), pages 949 - 955
NAT. MED., vol. 17, no. 12, December 2011 (2011-12-01), pages 1685 - 91
CLIN. PHARMACOL. THER., vol. 87, no. 5, May 2010 (2010-05-01), pages 586 - 92
CURR. OPIN. BIOTECHNOL., vol. 13, no. 6, December 2002 (2002-12-01), pages 609 - 14
NAT. BIOTECHNOL., vol. 23, no. 9, September 2005 (2005-09-01), pages 1126 - 36
GLYCOCONJ. J., vol. 30, no. 3, April 2013 (2013-04-01), pages 227 - 36
CANCER IMMUNOL IMMUNOTHER, vol. 55, no. 11, November 2006 (2006-11-01), pages 1337 - 47
J. PHARM. SCI., vol. 97, 2008, pages 2426 - 2447
ANAL. BIOCHEM., vol. 348, 2006, pages 24 - 39
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396 - 97
J. AM. MED. ASSOC., vol. 199, 1967, pages 519 - 24
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1 - 8
PNAS, vol. 82, 1985, pages 8404 - 8
PNAS, vol. 1972, 1980, pages 4505 - 8
PROTEINS, vol. 82, no. 8, August 2014 (2014-08-01), pages 1624 - 35
FRONT BIOSCI., vol. 13, 1 January 2008 (2008-01-01), pages 1619 - 33
See also references of EP 3543337A4
MOD. PATHOL., vol. 18, no. 10, October 2005 (2005-10-01), pages 1295 - 304
HUM. PATHOL., vol. 39, no. 1, January 2008 (2008-01-01), pages 126 - 36
INT. J. ONCOL., vol. 16, no. 1, January 2000 (2000-01-01), pages 55 - 64
PLOS ONE, vol. 9, no. 3, March 2014 (2014-03-01), pages e92742
HISTOPATHOLOGY, vol. 37, no. 3, September 2000 (2000-09-01), pages 218 - 23
J. PATHOL., vol. 200, no. 3, July 2003 (2003-07-01), pages 357 - 69
J. PATHOL., vol. 190, no. 4, March 2000 (2000-03-01), pages 437 - 43
INT. J. ONCOL., vol. 24, no. 1, January 2004 (2004-01-01), pages 107 - 13
MOD. PATHOL., vol. 17, no. 2, February 2004 (2004-02-01), pages 180 - 8
GYNECOL. ONCOL., vol. 105, no. 3, June 2007 (2007-06-01), pages 695 - 702
AM. J. CLIN. PATHOL., vol. 122, no. 1, July 2004 (2004-07-01), pages 61 - 9
PATHOL. RES. PRACT., vol. 206, no. 8, 15 August 2010 (2010-08-15), pages 585 - 9
TAKASHI TSURUO: "Molecular Target Therapy of Cancer", 15 September 2008, NANZANDO CO., LTD., pages: 332 - 336
J. NUCL. MED., vol. 57, no. 7, July 2016 (2016-07-01), pages 1105 - 1111
NUCL. MED. BIOL., vol. 37, no. 8, November 2010 (2010-11-01), pages 949 - 955
NAT. MED., vol. 17, no. 12, December 2011 (2011-12-01), pages 1685 - 91
CLIN. PHARMACOL. THER., vol. 87, no. 5, May 2010 (2010-05-01), pages 586 - 92
CURR. OPIN. BIOTECHNOL., vol. 13, no. 6, December 2002 (2002-12-01), pages 609 - 14
NAT. BIOTECHNOL., vol. 23, no. 9, September 2005 (2005-09-01), pages 1126 - 36
GLYCOCONJ. J., vol. 30, no. 3, April 2013 (2013-04-01), pages 227 - 36
CANCER IMMUNOL IMMUNOTHER, vol. 55, no. 11, November 2006 (2006-11-01), pages 1337 - 47
J. PHARM. SCI., vol. 97, 2008, pages 2426 - 2447
ANAL. BIOCHEM., vol. 348, 2006, pages 24 - 39
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396 - 97
J. AM. MED. ASSOC., vol. 199, 1967, pages 519 - 24
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1 - 8
PNAS, vol. 82, 1985, pages 8404 - 8
PNAS, vol. 1972, 1980, pages 4505 - 8
PROTEINS, vol. 82, no. 8, August 2014 (2014-08-01), pages 1624 - 35
FRONT BIOSCI., vol. 13, 1 January 2008 (2008-01-01), pages 1619 - 33
See also references of EP 3543337A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
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