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Title:
NOVEL ANTI-HUMAN NGF ANTIBODY Fab FRAGMENT
Document Type and Number:
WIPO Patent Application WO/2016/190263
Kind Code:
A1
Abstract:
Provided are: an excellent anti-human NGF antibody fragment that maintains high neutralizing activity and exhibits localized action while reducing systemic side effects from systemic exposure; and a therapeutic procedure for postoperative pain using the antibody fragment. An anti-human NGF antibody Fab fragment which includes a heavy chain fragment comprising the amino acid sequence indicated in SEQ ID NO: 5 and a light chain comprising the amino acid sequence indicated in SEQ ID NO: 8.

Inventors:
TANAKA HIROTSUGU (JP)
FUJITA HIROTADA (JP)
AOKI TOSHIAKI (JP)
Application Number:
PCT/JP2016/065099
Publication Date:
December 01, 2016
Filing Date:
May 20, 2016
Export Citation:
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Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C12N15/09; A61K39/395; A61P25/04; A61P29/00; C07K16/22; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
WO2013022083A12013-02-14
Foreign References:
JP2014150761A2014-08-25
JP2012504106A2012-02-16
Other References:
LIU H ET AL.: "Heterogeneity of monoclonal antibodies.", J. PHARM. SCI., vol. 97, no. 7, 2008, pages 2426 - 2447, XP002530921
HUMPHREYS DP ET AL.: "Formation of dimeric Fabs in Escherichia coli: effect of hinge size and isotype, presence of interchain disulphide bond, Fab' expression levels, tail piece sequences and growth conditions.", J. IMMUNOL. METHODS, vol. 209, no. 2, 1997, pages 193 - 202, XP004103797
See also references of EP 3299461A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
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