Title:
NOVEL ANTI-INFLAMMATORY ANDROSTANE DERIVATIVES -17-CARBOXY-LACTONE SUBSTITUTED STEROIDS WITH AN ARYL-CARBOXYLIC ESTER IN POSITION 17.ALPHA
Document Type and Number:
WIPO Patent Application WO2003035668
Kind Code:
A3
Abstract:
Novel Anti-inflammatory Androstane DerivativesThere are provided compounds of formula (I) wherein R1 represents O, S or NH;R2 represents -C(=O)-aryl or -C(=O)-heteroaryl;R3 represents hydrogen, methyl (which may be in either the ( or ( configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and represents a single or a double bond;and salts and solvates thereof;process for preparing them, compositions containing them and their use in therapy.
Inventors:
BIGGADIKE KEITH (GB)
JONES PAUL (GB)
PAYNE JEREMY JOHN (GB)
JONES PAUL (GB)
PAYNE JEREMY JOHN (GB)
Application Number:
PCT/EP2002/011634
Publication Date:
July 31, 2003
Filing Date:
October 17, 2002
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
BIGGADIKE KEITH (GB)
JONES PAUL (GB)
PAYNE JEREMY JOHN (GB)
BIGGADIKE KEITH (GB)
JONES PAUL (GB)
PAYNE JEREMY JOHN (GB)
International Classes:
A61K9/12; A61K31/58; A61K31/585; A61P5/44; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P29/00; A61P37/08; C07J17/00; C07J31/00; C07J33/00; C07J43/00; (IPC1-7): C07J17/00; C07J31/00; A61K31/58; A61P5/44; A61P11/06
Domestic Patent References:
| WO1997024365A1 | 1997-07-10 |
Foreign References:
| US3856828A | 1974-12-24 | |||
| EP0057401A1 | 1982-08-11 | |||
| US3828080A | 1974-08-06 |
Other References:
ISOGAI M ET AL: "BINDING AFFINITIES OF MOMETASONE FUROATE AND RELATED COMPOUNDS INCLUDING ITS METABOLITES FOR THE GLUCOCORTICOID RECEPTOR OF RAT SKIN TISSUE", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 44, no. 2, 1993, pages 141 - 145, XP001040943, ISSN: 0960-0760
POPPER T L ET AL: "STRUCTURE-ACTIVITY RELATIONSHIP OF A SERIES OF NOVEL TOPICAL CORTICOSTEROIDS", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 27, no. 4 - 6, 1987, pages 837 - 843, XP000972215, ISSN: 0022-4731
SHAPIRO E L ET AL: "17 HETEROAROYL ESTERS OF CORTICOSTEROIDS 2. 11-BETA HYDROXY SERIES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 30, no. 9, 1987, pages 1581 - 1588, XP002153839, ISSN: 0022-2623
POPPER T L ET AL: "STRUCTURE-ACTIVITY RELATIONSHIP OF A SERIES OF NOVEL TOPICAL CORTICOSTEROIDS", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 27, no. 4 - 6, 1987, pages 837 - 843, XP000972215, ISSN: 0022-4731
SHAPIRO E L ET AL: "17 HETEROAROYL ESTERS OF CORTICOSTEROIDS 2. 11-BETA HYDROXY SERIES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 30, no. 9, 1987, pages 1581 - 1588, XP002153839, ISSN: 0022-2623
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