Title:
NOVEL ANTI-PD-L1 ANTIBODIES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/156507
Kind Code:
A1
Abstract:
Novel single domain antibodies and antibody fragments specifically binding to PD-L1, and compositions comprising said antibodies or antibody fragments are provided. Nucleic acid encoding said antibodies or antibody fragments, host cells comprising same, and related use are further provided. Furthermore, therapeutic use and diagnostic use of said antibodies and antibody fragments are provided. In particular, combined therapy of these antibodies and antibody fragments with other therapies such as treatment methods or therapeutic agents is provided.
Inventors:
GU CHUNYIN (CN)
ZHOU QIAN (CN)
KUANG ZHIHUI (CN)
LIU JUNJIAN (CN)
ZHOU QIAN (CN)
KUANG ZHIHUI (CN)
LIU JUNJIAN (CN)
Application Number:
PCT/CN2020/074095
Publication Date:
August 06, 2020
Filing Date:
January 31, 2020
Export Citation:
Assignee:
INNOVENT BIOLOGICS (SUZHOU) CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61K51/10; A61P35/00; C12N15/13; C12N15/85; G01N33/68
Domestic Patent References:
| WO2018024237A1 | 2018-02-08 | |||
| WO2017157334A1 | 2017-09-21 | |||
| WO2018233574A1 | 2018-12-27 | |||
| WO2009114335A2 | 2009-09-17 | |||
| WO2016000619A1 | 2016-01-07 |
Foreign References:
| CN109265548A | 2019-01-25 |
Other References:
DOUGAN, M.: "Targeting cytokine therapy to the pancreatic tumor microenvi- ronment using PD-L1 specific VHHs.", CANCER IMMUNOL RES., 30 April 2018 (2018-04-30), pages 389 - 401, XP055591626
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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