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Title:
NOVEL ANTI-TUMOR AGENT
Document Type and Number:
WIPO Patent Application WO/2019/188456
Kind Code:
A1
Abstract:
Provided are: a compound having an anti-tumor activity and a cancer metastasis inhibiting activity; and an anti-tumor agent containing the compound as an active ingredient. A compound represented by formula (1) (wherein the ring A represents a 5- to 6-membered ring which may have a substituent; R1 and R4 independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a cyano group, a C1-6 alkyl group, a halogenated C1-6 alkyl group or a C1-6 alkoxy group; each of the benzene ring B and the benzene ring C may further have a substituent; the (benzene ring B)-C(R2)(R3) group and the benzene ring C are bonded to different carbon atoms constituting the ring A, respectively; and R2 and R3 independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a cyano group, a C1-6 alkyl group, a halogenated C1-6 alkyl group or a C1-6 alkoxy group, or R2 and R3 together represent an oxo group or a hydroxyimino group) or a salt thereof.

Inventors:
YAMAUCHI, Akira (Kawasaki Gakuen Educational Foundation 577, Matsushima, Kurashiki-sh, Okayama 92, 〒7010192, JP)
CHOSHI, Tominari (985-1 Aza Sanzo, Higashimura-cho, Fukuyama-sh, Hiroshima 92, 〒7290292, JP)
Application Number:
JP2019/011009
Publication Date:
October 03, 2019
Filing Date:
March 15, 2019
Export Citation:
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Assignee:
KAWASAKI GAKUEN EDUCATIONAL FOUNDATION (577 Matsushima, Kurashiki-shi Okayama, 92, 〒7010192, JP)
FUKUYAMA UNIVERSITY (985-1, Aza Sanzo Higashimura-cho, Fukuyama-sh, Hiroshima 92, 〒7290292, JP)
International Classes:
C07D231/12; A61K31/415; A61K31/505; A61P35/00; C07D239/26
Domestic Patent References:
WO1999028301A11999-06-10
WO2015026646A12015-02-26
WO2018111904A12018-06-21
Foreign References:
JPH07165724A1995-06-27
JP2011524422A2011-09-01
JP2013538213A2013-10-10
Other References:
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Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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