NOVEL ANTIBACTERIAL COMPOUND AND USE THEREOF

WIPO Patent Application WO/2015/174747

A1

The present invention relates to: coralmycin A and B, which are novel compounds exhibiting antibacterial activity, an isomer thereof, a derivative thereof or a pharmaceutically acceptable salt thereof; a Corallococcus sp. strain producing the same; and an antibacterial use thereof. The coralmycin A and B have very strong antibacterial activity against antibiotic-resistant bacteria such as MRSA, QRSA, VRE and VISA and Acinetobacter baumannii, which is a multidrug-resistant bacterium, and against gram-positive bacteria and gram-negative bacteria. Therefore, the present invention can be very useful for prevention, treatment and alleviation of various bacterial infections, and thus can be widely applied to the medical supplies, quasi-drugs, food and feed industries.

KIM WON GON (KR)
KIM HYUN JU (KR)
KIM YU JIN (KR)
CHO KYUNG YUN (KR)

PCT/KR2015/004824

November 19, 2015

May 14, 2015

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KOREA RES INST OF BIOSCIENCE (KR)

C07C233/75; A23L33/00; A61K31/135; C07C235/56; C07C235/64

WO2015003816A2

2015-01-15

US20110117592A1

2011-05-19

ALEXANDER SCHMITZ ET AL.: "Corallorazines from the Myxobacterium Corallococcus coralloides", JOURNAL OF NATURAL PRODUCT, vol. 77, 14 January 2014 (2014-01-14), pages 159 - 163, XP002768724, DOI: doi:10.1021/np400740u
SASCHA BAUMANN ET AL.: "Cystobactamids: Myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, 22 December 2014 (2014-12-22), pages 14605 - 14609, XP055187824, DOI: doi:10.1002/anie.201409964

SON, MIN (KR)
손민 (KR)

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