Title:
NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/006321
Kind Code:
A3
Abstract:
The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
Inventors:
CARR GRANT J (US)
MANNING DAVID D (US)
YANG ZHICAI (US)
GUO CHENG (US)
MAENG JUN-HO (US)
RABENSTEIN JOHN (US)
MICHELS PETER C (US)
CHASE MATTHEW W (US)
MANNING DAVID D (US)
YANG ZHICAI (US)
GUO CHENG (US)
MAENG JUN-HO (US)
RABENSTEIN JOHN (US)
MICHELS PETER C (US)
CHASE MATTHEW W (US)
Application Number:
PCT/US2011/043028
Publication Date:
August 01, 2013
Filing Date:
July 06, 2011
Export Citation:
Assignee:
ALBANY MOLECULAR RES INC (US)
CARR GRANT J (US)
MANNING DAVID D (US)
YANG ZHICAI (US)
GUO CHENG (US)
MAENG JUN-HO (US)
RABENSTEIN JOHN (US)
MICHELS PETER C (US)
CHASE MATTHEW W (US)
CARR GRANT J (US)
MANNING DAVID D (US)
YANG ZHICAI (US)
GUO CHENG (US)
MAENG JUN-HO (US)
RABENSTEIN JOHN (US)
MICHELS PETER C (US)
CHASE MATTHEW W (US)
International Classes:
C07C50/22
Domestic Patent References:
| WO2008079339A2 | 2008-07-03 |
Foreign References:
| US4375542A | 1983-03-01 | |||
| US7745644B2 | 2010-06-29 |
Other References:
ASOLKAR R.N. ET AL.: "Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola", J ANTIBIOT, vol. 63, no. 1, January 2010 (2010-01-01), TOKYO, pages 1 - 10, XP055082155, Retrieved from the Internet
BOEHM ET AL.: "Novel Inhibitors of DNA Gyrase: 3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening", J MED CHEM., vol. 43, 2000, pages 2664 - 2674, XP002953890
SELVAM ET AL.: "Highly efficient nitration of phenolic compounds by zlrconyl nitrate", TETRAHEDRON LETTERS, vol. 47, 2006, pages 2507 - 2509, XP025003874
MULLEN ET AL.: "(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one]; a Conformationally Restricted Analogue of Acetylcholine, Is a Highly Selective Full Agonist al the alpha7 Nicotinic Acetylcholine Receptor", J MED CHEM., vol. 43, 2000, pages 4045 - 4050, XP002940689
BOONS G.J. ET AL.: "Post-Graduate Chemistry Series, Organic Synthesis with Carbohydrates", 2000, SHEFFIELD ACADEMIC PRESS, ISBN: 1-85075-913-8, pages: 26 - 40, XP003031084
TAKEDA U. ET AL.: "SF2446. New Benzo[a]naphthacene Quinone Antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics", THE JOURNAL OF ANTIBIOTICS, vol. 41, no. 4, 1988, pages 417 - 424, XP055082221
See also references of EP 2593112A4
BOEHM ET AL.: "Novel Inhibitors of DNA Gyrase: 3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening", J MED CHEM., vol. 43, 2000, pages 2664 - 2674, XP002953890
SELVAM ET AL.: "Highly efficient nitration of phenolic compounds by zlrconyl nitrate", TETRAHEDRON LETTERS, vol. 47, 2006, pages 2507 - 2509, XP025003874
MULLEN ET AL.: "(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one]; a Conformationally Restricted Analogue of Acetylcholine, Is a Highly Selective Full Agonist al the alpha7 Nicotinic Acetylcholine Receptor", J MED CHEM., vol. 43, 2000, pages 4045 - 4050, XP002940689
BOONS G.J. ET AL.: "Post-Graduate Chemistry Series, Organic Synthesis with Carbohydrates", 2000, SHEFFIELD ACADEMIC PRESS, ISBN: 1-85075-913-8, pages: 26 - 40, XP003031084
TAKEDA U. ET AL.: "SF2446. New Benzo[a]naphthacene Quinone Antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics", THE JOURNAL OF ANTIBIOTICS, vol. 41, no. 4, 1988, pages 417 - 424, XP055082221
See also references of EP 2593112A4
Attorney, Agent or Firm:
EVANS, Georgia et al. (70 Linden Oaks Suite 21, Rochester NY, US)
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