Title:
NOVEL ANTIBIOTICS RK-1061 AND PROCESS FOR PREPARING THE SAME
Document Type and Number:
WIPO Patent Application WO/1997/041248
Kind Code:
A1
Abstract:
Antibiotics RK-1061 having a novel chemical structure and a process for preparing the same. They have a structural formula represented by general formula (I) wherein A represents R1 or R1CH(OR2)CH2, R2 represents a 3-methylglutaric acid residue and R3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061 from the culture. Streptomyces sp.SN-1061M (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.
Inventors:
KIMURA KEN-ICHI (JP)
IKEDA YOSHIKAZU (JP)
KAGAMI SHINOBU (JP)
TAKAHASHI HIDETOSHI (JP)
TAKAHASHI KOUSAKU (JP)
YOSHIHAMA MAKOTO (JP)
UBUKATA MAKOTO (JP)
ISONO KIYOSHI (JP)
IKEDA YOSHIKAZU (JP)
KAGAMI SHINOBU (JP)
TAKAHASHI HIDETOSHI (JP)
TAKAHASHI KOUSAKU (JP)
YOSHIHAMA MAKOTO (JP)
UBUKATA MAKOTO (JP)
ISONO KIYOSHI (JP)
Application Number:
PCT/JP1997/001466
Publication Date:
November 06, 1997
Filing Date:
April 25, 1997
Export Citation:
Assignee:
SNOW BRAND MILK PRODUCTS CO LTD (JP)
KIMURA KEN ICHI (JP)
IKEDA YOSHIKAZU (JP)
KAGAMI SHINOBU (JP)
TAKAHASHI HIDETOSHI (JP)
TAKAHASHI KOUSAKU (JP)
YOSHIHAMA MAKOTO (JP)
UBUKATA MAKOTO (JP)
ISONO KIYOSHI (JP)
KIMURA KEN ICHI (JP)
IKEDA YOSHIKAZU (JP)
KAGAMI SHINOBU (JP)
TAKAHASHI HIDETOSHI (JP)
TAKAHASHI KOUSAKU (JP)
YOSHIHAMA MAKOTO (JP)
UBUKATA MAKOTO (JP)
ISONO KIYOSHI (JP)
International Classes:
C07H19/06; C07H19/067; C07H19/073; C12N1/20; C12P19/38; (IPC1-7): C12P17/16; C12N1/20; C07H19/06; A61K31/70
Other References:
TETRAHEDRON LETTERS, (1992), Vol. 33, No. 38, SPENCER KNAPP et al., "Synthesis of the Liposidomycin Diazepanone", pages 5485-5486.
THE JOURNAL OF ANTIBIOTIC, (1985), Vol. 38, No. 11, KIYOSHI ISONO et al., "Liposidomycins: Novel Nucleoside Antibiotics Which Inhibit Bacterial Peptidoglycan Synthesis", pages 1617-1621.
J. ORG. CHEM., (1992), Vol. 57, No. 24, MAKOTO UBUKATA et al., "Structure Elucidation of Liposidomycin, a Class of Complex Lipid", pages 6392-6403.
AGRIC. BIOL. CHEM., (1989), Vol. 53, No. 7, KEN-ICHI KIMURA et al., "Liposidomycin C Inhibits Phospho-N-acetylmuramyl-pentapeptide Transferase in Peptidoglycan Synthesis of Escherichia Coli Y-10", pages 1811-1815.
JOURNAL OF THE AGRICULTURAL CHEMICAL SOC. OF JAPAN, (1988), Vol. 62, No. 11, SHIN UBUKATA, "Chemical Studies on Novel Antibiotics (in Japanese)", pages 1629-1636.
"Microbiological Industry (in Japanese)", K.K. ASAKURA SHOTEN, (1956), pages 609-620.
See also references of EP 1001035A4
THE JOURNAL OF ANTIBIOTIC, (1985), Vol. 38, No. 11, KIYOSHI ISONO et al., "Liposidomycins: Novel Nucleoside Antibiotics Which Inhibit Bacterial Peptidoglycan Synthesis", pages 1617-1621.
J. ORG. CHEM., (1992), Vol. 57, No. 24, MAKOTO UBUKATA et al., "Structure Elucidation of Liposidomycin, a Class of Complex Lipid", pages 6392-6403.
AGRIC. BIOL. CHEM., (1989), Vol. 53, No. 7, KEN-ICHI KIMURA et al., "Liposidomycin C Inhibits Phospho-N-acetylmuramyl-pentapeptide Transferase in Peptidoglycan Synthesis of Escherichia Coli Y-10", pages 1811-1815.
JOURNAL OF THE AGRICULTURAL CHEMICAL SOC. OF JAPAN, (1988), Vol. 62, No. 11, SHIN UBUKATA, "Chemical Studies on Novel Antibiotics (in Japanese)", pages 1629-1636.
"Microbiological Industry (in Japanese)", K.K. ASAKURA SHOTEN, (1956), pages 609-620.
See also references of EP 1001035A4
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